一种由结构变异音符组成的新兴旋律——评论Chen等人的“中国人群泛癌中RET融合的融合特征：一项全面的基因组分析”

IF 5 2区医学 Q2 Medicine

Translational Oncology Pub Date : 2025-08-22 DOI:10.1016/j.tranon.2025.102508

Lv Wu, Qing Zhou, Chang Lu

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引用次数: 0

摘要

RET融合物的鉴定显著推进了肺癌精准医学的发展；然而，对其结构特征的了解是有限的。本文讨论了Chen等人最近的一项综合研究，该研究使用DNA和RNA测序分析了中国大型泛癌症队列中的RET融合。我们强调其对理解融合结构、诊断意义以及亚洲和西方人群之间差异的贡献，为未来的研究方向奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An emerging melody composed of the notes from structural variants - Comment on ‘The fusion characteristics of RET fusion in pan-cancer among the Chinese population: A comprehensive genomic analysis’ by Chen et al

The identification of RET fusions has significantly advanced precision medicine in lung cancer; however, understanding of the structural features is limited. This commentary discusses a recent comprehensive study by Chen et al. analyzing RET fusions in a large Chinese pan-cancer cohort using DNA and RNA sequencing. We highlight its contribution to understanding fusion structure, diagnostic implications, and differences between Asian and Western populations, setting the stage for future research directions.

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来源期刊

Translational Oncology ONCOLOGY-

CiteScore

8.40

自引率

2.00%

发文量

314

审稿时长

54 days

期刊介绍： Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.