早期帕金森病患者嗅道的变化：DTI嗅道造影研究

IF 1.8 Q3 CLINICAL NEUROLOGY

Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI:10.1016/j.prdoa.2025.100396

Pasquale Nigro , Andrea Chiappiniello , Filippo Bucherini , Pietro Chiarini , Alessandro Mechelli , Carlo Maremmani , Federico Paolini Paoletti , Roberto Tarducci , Andrea Fiacca , Lucilla Parnetti , Nicola Tambasco

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引用次数: 0

摘要

嗅觉障碍是帕金森病（PD）的临床特征，即使在早期阶段也是如此。弥散张量成像纤维跟踪分析（DTI-FTA）能够突出PD患者嗅束的变化，但在PD的早期阶段，这种分析尚未得到研究。我们用DTI-FTA对PD （ePD）早期的嗅道进行了研究。方法采用意大利嗅觉识别测试（IOIT）、运动障碍学会统一帕金森病评定量表第三部分（MDS-UPDRS-III）和Hoehn and Yahr （H&；Y）量表对所有患者进行评估。采用3t MRI进行弥散成像。结果共纳入PD患者26例，健康受试者20例。所有PD患者均出现低血压。PD组嗅道DTI-FTA平均扩散系数（MD）显著升高，嗅道体积明显减小。仅在PD组中，MD和年龄具有显著的多重相关性。结论dti - fta可识别低浓度ePD患者嗅道微结构变化。

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Changes in the olfactory tract of patients with early Parkinson’s disease: A DTI tractography study

Introduction

olfactory impairment is a clinical feature of Parkinson’s disease (PD) even in the early phases. Diffusion tensor imaging fiber tracking analysis (DTI-FTA) has been able to highlight changes in the olfactory tract in PD, however in early phases of PD this analysis has not been investigated. We investigated the olfactory tract by DTI-FTA in early stages of PD (ePD).

Methods

All patients were assessed using the Italian Olfactory Identification Test (IOIT), the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale-Part III (MDS-UPDRS-III) and the Hoehn and Yahr (H&Y) scale. Diffusion imaging was conducted by 3 T MRI.

Results

Overall, 26 PD patients and 20 healthy subject were recruited. Hyposmia was observed in all PD patients. DTI-FTA of the olfactory tract showed significant mean diffusivity (MD) increases and a tract volume decrease for PD group. MD and age, only in the PD group, were significant for multiple correlations.