Niklas Sarelin , Valtteri Kairaluoma , Juha Saarnio , Joonas H. Kauppila , Jan Böhm , Heikki Huhta , Juha P. Väyrynen , Olli Helminen
{"title":"肝细胞癌的肿瘤出芽及间质比。","authors":"Niklas Sarelin , Valtteri Kairaluoma , Juha Saarnio , Joonas H. Kauppila , Jan Böhm , Heikki Huhta , Juha P. Väyrynen , Olli Helminen","doi":"10.1016/j.humpath.2025.105937","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Tumour budding has been linked with poor prognosis in hepatocellular carcinoma (HCC), while the prognostic value of tumour-stroma ratio (TSR) remains unclear. We assessed the prognostic value of tumour buds and TSR in HCC.</div></div><div><h3>Methods</h3><div>506 HCC cases were included. Survival analysis was performed separately for surgical (n=101) and non-surgical patients (n=405) based on the presence of tumour buds, and having low TSR (<50 %) and high TSR (≥50 %). Bud-positive patients were further categorised according to tumour bud quantity (1–4 buds, 5–9 buds, and ≥10 buds), and the presence of tumour buds accross multiple sections of the same tumour was evaluated. We also analysed the correlation of tumour buds and TSR between biopsy and resection samples.</div></div><div><h3>Results</h3><div>Positive tumour budding was not associated with increased 5-year overall mortality in multivariable analysis (HR 2.00, 95 % CI, 0.98–4.07), but was an independent risk factor for disease-specific mortality (HR 2.53, 95 % CI, 1.06–6.02, P = 0.036). The presence of ≥10 buds was an independent risk factor of overall- and disease-specific mortality in multivariable analysis. Tumour buds were found in 77% of slides in bud-positive patients. TSR was not linked with 5-year overall survival or disease-specific survival. Biopsy samples demonstrated a low sensitivity of 22 % in identifying tumour budding compared to the resection samples.</div></div><div><h3>Conclusion</h3><div>Tumour budding was an independent risk factor for disease-specific mortality in surgically treated HCC patients, with higher bud counts indicating poorer outcomes. Tumour buds were consistently found across slides. Furthermore, our results suggest that tumour buds are most reliably evaluated using resection samples.</div></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"165 ","pages":"Article 105937"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tumour budding and tumour-stroma ratio in hepatocellular carcinoma\",\"authors\":\"Niklas Sarelin , Valtteri Kairaluoma , Juha Saarnio , Joonas H. Kauppila , Jan Böhm , Heikki Huhta , Juha P. Väyrynen , Olli Helminen\",\"doi\":\"10.1016/j.humpath.2025.105937\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Tumour budding has been linked with poor prognosis in hepatocellular carcinoma (HCC), while the prognostic value of tumour-stroma ratio (TSR) remains unclear. We assessed the prognostic value of tumour buds and TSR in HCC.</div></div><div><h3>Methods</h3><div>506 HCC cases were included. Survival analysis was performed separately for surgical (n=101) and non-surgical patients (n=405) based on the presence of tumour buds, and having low TSR (<50 %) and high TSR (≥50 %). Bud-positive patients were further categorised according to tumour bud quantity (1–4 buds, 5–9 buds, and ≥10 buds), and the presence of tumour buds accross multiple sections of the same tumour was evaluated. We also analysed the correlation of tumour buds and TSR between biopsy and resection samples.</div></div><div><h3>Results</h3><div>Positive tumour budding was not associated with increased 5-year overall mortality in multivariable analysis (HR 2.00, 95 % CI, 0.98–4.07), but was an independent risk factor for disease-specific mortality (HR 2.53, 95 % CI, 1.06–6.02, P = 0.036). The presence of ≥10 buds was an independent risk factor of overall- and disease-specific mortality in multivariable analysis. Tumour buds were found in 77% of slides in bud-positive patients. TSR was not linked with 5-year overall survival or disease-specific survival. Biopsy samples demonstrated a low sensitivity of 22 % in identifying tumour budding compared to the resection samples.</div></div><div><h3>Conclusion</h3><div>Tumour budding was an independent risk factor for disease-specific mortality in surgically treated HCC patients, with higher bud counts indicating poorer outcomes. Tumour buds were consistently found across slides. Furthermore, our results suggest that tumour buds are most reliably evaluated using resection samples.</div></div>\",\"PeriodicalId\":13062,\"journal\":{\"name\":\"Human pathology\",\"volume\":\"165 \",\"pages\":\"Article 105937\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0046817725002242\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human pathology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0046817725002242","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
Tumour budding and tumour-stroma ratio in hepatocellular carcinoma
Objectives
Tumour budding has been linked with poor prognosis in hepatocellular carcinoma (HCC), while the prognostic value of tumour-stroma ratio (TSR) remains unclear. We assessed the prognostic value of tumour buds and TSR in HCC.
Methods
506 HCC cases were included. Survival analysis was performed separately for surgical (n=101) and non-surgical patients (n=405) based on the presence of tumour buds, and having low TSR (<50 %) and high TSR (≥50 %). Bud-positive patients were further categorised according to tumour bud quantity (1–4 buds, 5–9 buds, and ≥10 buds), and the presence of tumour buds accross multiple sections of the same tumour was evaluated. We also analysed the correlation of tumour buds and TSR between biopsy and resection samples.
Results
Positive tumour budding was not associated with increased 5-year overall mortality in multivariable analysis (HR 2.00, 95 % CI, 0.98–4.07), but was an independent risk factor for disease-specific mortality (HR 2.53, 95 % CI, 1.06–6.02, P = 0.036). The presence of ≥10 buds was an independent risk factor of overall- and disease-specific mortality in multivariable analysis. Tumour buds were found in 77% of slides in bud-positive patients. TSR was not linked with 5-year overall survival or disease-specific survival. Biopsy samples demonstrated a low sensitivity of 22 % in identifying tumour budding compared to the resection samples.
Conclusion
Tumour budding was an independent risk factor for disease-specific mortality in surgically treated HCC patients, with higher bud counts indicating poorer outcomes. Tumour buds were consistently found across slides. Furthermore, our results suggest that tumour buds are most reliably evaluated using resection samples.
期刊介绍:
Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.