C. Mias, C. Géniès, M. Maître, T. Nocera, A. Bacquey, J. Kim, A. Simcic-Mori, E. Gravier, C. Lauze, A. Stennevin, G. Doat, A. Castinel, E. Gontier, S. Bessou-Touya, P. Reygagne, J. H. Saurat, H. Duplan
{"title":"微粉刺酮生态系统的多组学和结构分析为含有水飞蓟果提取物的抗痤疮配方的临床疗效提供了见解","authors":"C. Mias, C. Géniès, M. Maître, T. Nocera, A. Bacquey, J. Kim, A. Simcic-Mori, E. Gravier, C. Lauze, A. Stennevin, G. Doat, A. Castinel, E. Gontier, S. Bessou-Touya, P. Reygagne, J. H. Saurat, H. Duplan","doi":"10.1155/dth/8869125","DOIUrl":null,"url":null,"abstract":"<p><b>Background:</b> Antiacne dermocosmetics are effective supportive care for managing mild-to-moderate acne. Exploration of the microcomedone ecosystem can provide insights into specific targets for antiacne products.</p><p><b>Objective:</b> To analyze changes in infra-clinical acne lesions in subjects using a formulation containing <i>Silybum marianum</i> fruit extract (SMFE) to manage mild-to-moderate facial acne.</p><p><b>Methods:</b> A controlled, randomized, open-label study was conducted in adults and adolescents with predominantly retentional acne lesions: the test group received the SMFE-based product, and the control group received a hydrating skincare product. After evaluating the clinical efficacy of the study product, a multiomics approach was used to assess metabolome, lipidome, and microbiome changes in the microcomedone ecosystem. Two-dimensional ultrastructural imaging was also performed on extracted microcomedones.</p><p><b>Results:</b> After 2 months of twice-daily application of the study product, acne lesion severity was effectively reduced in the test group (<i>N</i> = 20) compared to the control group (<i>N</i> = 20). Ultrastructural imaging clearly showed alterations in microcomedones in the test group, which, together with evidence of decreased levels of several cellular components, demonstrated the comedolytic effect of the product. Specific changes also occurred at the microbiota and lipid levels: compared to controls, the relative abundance of <i>Malassezia globosa</i> fungi significantly decreased (<i>p</i> < 0.05), along with the levels of some proinflammatory lipids. These lipolytic fungi could be key targets of the antiacne product.</p><p><b>Conclusion:</b> Our integrative analysis demonstrated that the SMFE-based product acts on the four main pillars of acne: hyperkeratosis, skin dysbiosis, hyperseborrhea, and proinflammatory lipids.</p><p><b>Trial Registration:</b> ClinicalTrials.gov Identifier: NCT05640388</p>","PeriodicalId":11045,"journal":{"name":"Dermatologic Therapy","volume":"2025 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/dth/8869125","citationCount":"0","resultStr":"{\"title\":\"Multiomics and Structural Analysis of the Microcomedone Ecosystem Provides Insights Into the Clinical Efficacy of an Antiacne Formulation Containing Silybum marianum Fruit Extract\",\"authors\":\"C. Mias, C. Géniès, M. Maître, T. Nocera, A. Bacquey, J. Kim, A. Simcic-Mori, E. Gravier, C. Lauze, A. Stennevin, G. Doat, A. Castinel, E. Gontier, S. Bessou-Touya, P. Reygagne, J. H. Saurat, H. Duplan\",\"doi\":\"10.1155/dth/8869125\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Background:</b> Antiacne dermocosmetics are effective supportive care for managing mild-to-moderate acne. Exploration of the microcomedone ecosystem can provide insights into specific targets for antiacne products.</p><p><b>Objective:</b> To analyze changes in infra-clinical acne lesions in subjects using a formulation containing <i>Silybum marianum</i> fruit extract (SMFE) to manage mild-to-moderate facial acne.</p><p><b>Methods:</b> A controlled, randomized, open-label study was conducted in adults and adolescents with predominantly retentional acne lesions: the test group received the SMFE-based product, and the control group received a hydrating skincare product. After evaluating the clinical efficacy of the study product, a multiomics approach was used to assess metabolome, lipidome, and microbiome changes in the microcomedone ecosystem. Two-dimensional ultrastructural imaging was also performed on extracted microcomedones.</p><p><b>Results:</b> After 2 months of twice-daily application of the study product, acne lesion severity was effectively reduced in the test group (<i>N</i> = 20) compared to the control group (<i>N</i> = 20). Ultrastructural imaging clearly showed alterations in microcomedones in the test group, which, together with evidence of decreased levels of several cellular components, demonstrated the comedolytic effect of the product. Specific changes also occurred at the microbiota and lipid levels: compared to controls, the relative abundance of <i>Malassezia globosa</i> fungi significantly decreased (<i>p</i> < 0.05), along with the levels of some proinflammatory lipids. 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Multiomics and Structural Analysis of the Microcomedone Ecosystem Provides Insights Into the Clinical Efficacy of an Antiacne Formulation Containing Silybum marianum Fruit Extract
Background: Antiacne dermocosmetics are effective supportive care for managing mild-to-moderate acne. Exploration of the microcomedone ecosystem can provide insights into specific targets for antiacne products.
Objective: To analyze changes in infra-clinical acne lesions in subjects using a formulation containing Silybum marianum fruit extract (SMFE) to manage mild-to-moderate facial acne.
Methods: A controlled, randomized, open-label study was conducted in adults and adolescents with predominantly retentional acne lesions: the test group received the SMFE-based product, and the control group received a hydrating skincare product. After evaluating the clinical efficacy of the study product, a multiomics approach was used to assess metabolome, lipidome, and microbiome changes in the microcomedone ecosystem. Two-dimensional ultrastructural imaging was also performed on extracted microcomedones.
Results: After 2 months of twice-daily application of the study product, acne lesion severity was effectively reduced in the test group (N = 20) compared to the control group (N = 20). Ultrastructural imaging clearly showed alterations in microcomedones in the test group, which, together with evidence of decreased levels of several cellular components, demonstrated the comedolytic effect of the product. Specific changes also occurred at the microbiota and lipid levels: compared to controls, the relative abundance of Malassezia globosa fungi significantly decreased (p < 0.05), along with the levels of some proinflammatory lipids. These lipolytic fungi could be key targets of the antiacne product.
Conclusion: Our integrative analysis demonstrated that the SMFE-based product acts on the four main pillars of acne: hyperkeratosis, skin dysbiosis, hyperseborrhea, and proinflammatory lipids.
期刊介绍：
Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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