在质子闪光的背景下，在保留健康组织的情况下，原位胶质母细胞瘤患者来源的异种移植物的治疗效果没有差异

IF 2.7 3区医学 Q3 ONCOLOGY

Clinical and Translational Radiation Oncology Pub Date : 2025-09-19 DOI:10.1016/j.ctro.2025.101050

Taylor L. Schanel , Manoj Kumar , Lauren C. Nassour-Caswell , Sreelakshmi Cherakara , Rhea Pandit , Andee M. Beierle , Joshua C. Anderson , Patrica H. Hicks , Rex Cardan , Anita B. Hjelmeland , Christopher D. Willey

{"title":"在质子闪光的背景下，在保留健康组织的情况下，原位胶质母细胞瘤患者来源的异种移植物的治疗效果没有差异","authors":"Taylor L. Schanel , Manoj Kumar , Lauren C. Nassour-Caswell , Sreelakshmi Cherakara , Rhea Pandit , Andee M. Beierle , Joshua C. Anderson , Patrica H. Hicks , Rex Cardan , Anita B. Hjelmeland , Christopher D. Willey","doi":"10.1016/j.ctro.2025.101050","DOIUrl":null,"url":null,"abstract":"<div><div>Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers. Both conventional and FLASH radiotherapy yielded similar survival benefits; however, conventional radiotherapy resulted in greater normal tissue DNA and RNA damage.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"56 ","pages":"Article 101050"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"No differences in therapeutic efficacy while sparing healthy tissue for orthotopic glioblastoma patient-derived xenografts in context of proton FLASH\",\"authors\":\"Taylor L. Schanel , Manoj Kumar , Lauren C. Nassour-Caswell , Sreelakshmi Cherakara , Rhea Pandit , Andee M. Beierle , Joshua C. Anderson , Patrica H. Hicks , Rex Cardan , Anita B. Hjelmeland , Christopher D. Willey\",\"doi\":\"10.1016/j.ctro.2025.101050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers. Both conventional and FLASH radiotherapy yielded similar survival benefits; however, conventional radiotherapy resulted in greater normal tissue DNA and RNA damage.</div></div>\",\"PeriodicalId\":10342,\"journal\":{\"name\":\"Clinical and Translational Radiation Oncology\",\"volume\":\"56 \",\"pages\":\"Article 101050\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Translational Radiation Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405630825001429\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Radiation Oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405630825001429","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

通过DNA和RNA损伤反应标志物比较超高剂量率（FLASH-RT）和常规质子束放疗对颅内胶质母细胞瘤PDX的肿瘤控制和正常组织毒性。常规放疗和FLASH放疗的生存率相似；然而，常规放疗导致更大的正常组织DNA和RNA损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

No differences in therapeutic efficacy while sparing healthy tissue for orthotopic glioblastoma patient-derived xenografts in context of proton FLASH

Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers. Both conventional and FLASH radiotherapy yielded similar survival benefits; however, conventional radiotherapy resulted in greater normal tissue DNA and RNA damage.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊