NutriConnect：通过可持续的解决方案和伙伴关系加强健康和粮食安全：一项务实的比较效果试验的设计和方案。

IF 1.9 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary clinical trials Pub Date : 2025-09-17 DOI:10.1016/j.cct.2025.108083

Sang Gune K. Yoo , Rachel G. Tabak , Stephanie Mazzucca-Ragan , Allison Primo , Doneisha Bohannon , Derek Hashimoto , Charles W. Goss , Jason HY Wu , Eghonghon Eromosele , Ihab Hassanieh , Adam Hively , Abygail Martinez , Jinli Wang , Mark D. Huffman , Jing Li

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引用次数: 0

摘要

背景：粮食不安全和不良饮食摄入导致健康差异，特别是在社会经济弱势人群中。生产处方项目旨在改善饮食敏感人群获得水果和蔬菜（F&V）的机会，但相对效果的数据有限。目的：比较两种农产品处方策略，即NutriConnect Credit（杂货券）和NutriConnect Delivery（送货上门的F&V餐盒），对近期因饮食敏感疾病住院的社会经济弱势人群的饮食摄入、食品安全和健康结果的影响。方法：在这项三组试点试验中，最近住院的食物或经济不安全且心血管风险升高的成年人被随机（1:1:1）分配到信贷、交付或强化常规护理组。主要结局是6 个月时两组间F&V摄入量变化的差异。次要结局包括粮食安全和自我报告的健康相关生活质量。使用PRISM/RE-AIM框架评估实施结果。结论：NutriConnect旨在为两种农产品处方策略的有效性和可行性提供证据，为可扩展的“食物即药物”计划提供信息，该计划针对营养相关的健康差异。试验注册号：NCT06263751。

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NutriConnect: Enhancing health and food security through sustainable solutions and partnerships: Design and protocol of a pragmatic comparative effectiveness trial

Background

Food insecurity and poor dietary intake contribute to health disparities, particularly among socioeconomically disadvantaged populations. Produce prescription programs aim to improve access to fruits and vegetables (F&V) for those with diet-sensitive conditions, but comparative effectiveness data are limited.

Objective

To compare the impact of two produce prescription strategies, NutriConnect Credit (grocery coupons) and NutriConnect Delivery (home-delivered F&V boxes), on dietary intake, food security, and health outcomes among socioeconomically disadvantaged populations who have been recently hospitalized with diet-sensitive conditions.

Methods

In this three-arm pilot trial, recently hospitalized adults with food or financial insecurity and elevated cardiovascular risk were randomized (1:1:1) to Credit, Delivery, or enhanced usual care. The primary outcome is between group difference in change in F&V intake at 6 months. Secondary outcomes include food security and self-reported health-related quality of life. Implementation outcomes are assessed using the PRISM/RE-AIM framework.

Conclusion

NutriConnect seeks to provide evidence on the effectiveness and feasibility of two produce prescription strategies to inform scalable “Food is Medicine” programs targeting nutrition-related health disparities.

Trial registration number: NCT06263751

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来源期刊

Contemporary clinical trials 医学-药学

CiteScore

3.70

自引率

4.50%

发文量

281

审稿时长

44 days

期刊介绍： Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.