M. Divya Gnaneswari, C. Raghavan, L. Bruno Chandrasekar, M. Karunakaran, L. Saravanan, S. Vimal, Saravanan Rajendran, Sonaimuthu Mohandoss, Subramanian Palanisamy, J. Thirumalai, P. Shunmuga Sundaram
{"title":"钒掺杂ZnO纳米颗粒增强抗菌和抗癌活性:掺杂浓度的影响","authors":"M. Divya Gnaneswari, C. Raghavan, L. Bruno Chandrasekar, M. Karunakaran, L. Saravanan, S. Vimal, Saravanan Rajendran, Sonaimuthu Mohandoss, Subramanian Palanisamy, J. Thirumalai, P. Shunmuga Sundaram","doi":"10.3103/S1068335625602535","DOIUrl":null,"url":null,"abstract":"<p>Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.</p>","PeriodicalId":503,"journal":{"name":"Bulletin of the Lebedev Physics Institute","volume":"52 8","pages":"395 - 408"},"PeriodicalIF":0.7000,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration\",\"authors\":\"M. Divya Gnaneswari, C. Raghavan, L. Bruno Chandrasekar, M. Karunakaran, L. Saravanan, S. Vimal, Saravanan Rajendran, Sonaimuthu Mohandoss, Subramanian Palanisamy, J. Thirumalai, P. Shunmuga Sundaram\",\"doi\":\"10.3103/S1068335625602535\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.</p>\",\"PeriodicalId\":503,\"journal\":{\"name\":\"Bulletin of the Lebedev Physics Institute\",\"volume\":\"52 8\",\"pages\":\"395 - 408\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-09-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of the Lebedev Physics Institute\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.3103/S1068335625602535\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of the Lebedev Physics Institute","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.3103/S1068335625602535","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration
Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.
期刊介绍:
Bulletin of the Lebedev Physics Institute is an international peer reviewed journal that publishes results of new original experimental and theoretical studies on all topics of physics: theoretical physics; atomic and molecular physics; nuclear physics; optics; lasers; condensed matter; physics of solids; biophysics, and others.