钯催化双C(sp3) -H功能化合成喹啉基内酯

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-19 DOI:10.1021/acs.orglett.5c03411

Dinesh G. Thakur, Mahesh A. Sonawane, Raj N. Patel, Subhash Chandra Ghosh

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引用次数: 0

摘要

我们开发了一种新的钯催化双C(sp3) -H功能化合成喹啉基内酯的方法。这种原子经济策略利用双功能的2-碘苯甲酸试剂在一个单一的催化循环。优化后的六氟-2-丙醇和乙酸的溶剂混合物显著提高了反应活性和选择性。这项工作为创建复杂的喹啉酯内酯支架提供了一个有价值的、位点选择性的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-Catalyzed Synthesis of Quinolinyl Lactones via Double C(sp3)–H Functionalization

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Palladium-Catalyzed Synthesis of Quinolinyl Lactones via Double C(sp3)–H Functionalization

We have developed a novel palladium-catalyzed method for synthesizing quinolinyl lactones via double C(sp³)–H functionalization. This atom-economical strategy utilizes a bifunctional 2-iodobenzoic acid reagent in a single catalytic cycle. An optimized solvent mixture of hexafluoro-2-propanol and acetic acid significantly enhanced reactivity and selectivity. This work provides a valuable, site-selective pathway for creating complex quinolinyl lactone scaffolds.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.