从青年到中年的长期估计身体活动模式与左心室结构和功能:一项30年的纵向研究。

IF 5.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Journal of the American Heart Association Pub Date : 2025-10-07 Epub Date: 2025-09-19 DOI:10.1161/JAHA.125.041256
Shunyi Li, Jianpin Luo, Shen Zhao, Haobin Zhou, Rongyang Xi, Jun Chen, Shichao Li, Kaiwei Li, Lin Song, Xiaolin Duan, Minhui Xu, Dingli Xu, Qingchun Zeng
{"title":"从青年到中年的长期估计身体活动模式与左心室结构和功能:一项30年的纵向研究。","authors":"Shunyi Li, Jianpin Luo, Shen Zhao, Haobin Zhou, Rongyang Xi, Jun Chen, Shichao Li, Kaiwei Li, Lin Song, Xiaolin Duan, Minhui Xu, Dingli Xu, Qingchun Zeng","doi":"10.1161/JAHA.125.041256","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The long-term effects of physical activity (PA) variability and cumulative PA (CPA) from young adulthood on cardiac remodeling remain controversial, and it is unclear whether these effects resemble those observed in elite athletes.</p><p><strong>Methods: </strong>A total of 1465 participants with recorded PA spanning a 30-year period were included in this study. PA levels were assessed at 9 follow-up visits using the CARDIA (Coronary Artery Risk Development in Young Adults) questionnaire. At year 30, left ventricular structure and function were evaluated using standardized echocardiography. CPA was calculated as the sum of average PA levels between consecutive visits multiplied by the corresponding intervisit intervals (in years). PA variability was quantified using average real variability (ARVPA). Additionally, participants were categorized into 4 groups: sustained low CPA and ARVPA group, low CPA and high ARVPA group, high CPA and low ARVPA group, and high CPA and high ARVPA group.</p><p><strong>Results: </strong>This study included 849 women (57.1%), 883 White participants (60.3%), and had a mean age of 55.3 years. Participants in the sustained high CPA group exhibited lower incidence of hypertension and diabetes. Multiple linear regression analyses showed that, compared with the sustained-low-CPA group, the sustained-high-CPA group and high-CPA and high-ARVPA group exhibited increased left ventricular end-diastolic dimension index, and the high-CPA and high-ARVPA group revealed an increased left ventricular mass index and left atrial volume index.</p><p><strong>Conclusions: </strong>Our study suggests that high CPA, even when accompanied with high variability in PA levels, is associated with alterations in left ventricular structure in midlife.</p>","PeriodicalId":54370,"journal":{"name":"Journal of the American Heart Association","volume":" ","pages":"e041256"},"PeriodicalIF":5.3000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-Term Estimated Physical Activity Patterns From Youth to Middle Age and Left Ventricular Structure and Function: A 30-Year Longitudinal Study.\",\"authors\":\"Shunyi Li, Jianpin Luo, Shen Zhao, Haobin Zhou, Rongyang Xi, Jun Chen, Shichao Li, Kaiwei Li, Lin Song, Xiaolin Duan, Minhui Xu, Dingli Xu, Qingchun Zeng\",\"doi\":\"10.1161/JAHA.125.041256\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The long-term effects of physical activity (PA) variability and cumulative PA (CPA) from young adulthood on cardiac remodeling remain controversial, and it is unclear whether these effects resemble those observed in elite athletes.</p><p><strong>Methods: </strong>A total of 1465 participants with recorded PA spanning a 30-year period were included in this study. PA levels were assessed at 9 follow-up visits using the CARDIA (Coronary Artery Risk Development in Young Adults) questionnaire. At year 30, left ventricular structure and function were evaluated using standardized echocardiography. CPA was calculated as the sum of average PA levels between consecutive visits multiplied by the corresponding intervisit intervals (in years). PA variability was quantified using average real variability (ARVPA). Additionally, participants were categorized into 4 groups: sustained low CPA and ARVPA group, low CPA and high ARVPA group, high CPA and low ARVPA group, and high CPA and high ARVPA group.</p><p><strong>Results: </strong>This study included 849 women (57.1%), 883 White participants (60.3%), and had a mean age of 55.3 years. Participants in the sustained high CPA group exhibited lower incidence of hypertension and diabetes. Multiple linear regression analyses showed that, compared with the sustained-low-CPA group, the sustained-high-CPA group and high-CPA and high-ARVPA group exhibited increased left ventricular end-diastolic dimension index, and the high-CPA and high-ARVPA group revealed an increased left ventricular mass index and left atrial volume index.</p><p><strong>Conclusions: </strong>Our study suggests that high CPA, even when accompanied with high variability in PA levels, is associated with alterations in left ventricular structure in midlife.</p>\",\"PeriodicalId\":54370,\"journal\":{\"name\":\"Journal of the American Heart Association\",\"volume\":\" \",\"pages\":\"e041256\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Heart Association\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1161/JAHA.125.041256\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Heart Association","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1161/JAHA.125.041256","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/19 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

摘要

背景:从青年期开始的体力活动(PA)变异性和累积PA (CPA)对心脏重塑的长期影响仍然存在争议,目前尚不清楚这些影响是否与精英运动员观察到的影响相似。方法:本研究共纳入1465名30年间有PA记录的参与者。在9次随访中使用CARDIA(年轻人冠状动脉风险发展)问卷评估PA水平。30岁时,使用标准化超声心动图评估左室结构和功能。CPA计算为连续就诊之间的平均PA水平乘以相应的就诊间隔(以年为单位)。利用平均真实变异性(ARVPA)量化PA变异性。将参与者分为持续低CPA和ARVPA组、低CPA和高ARVPA组、高CPA和低ARVPA组、高CPA和高ARVPA组。结果:本研究纳入849名女性(57.1%),883名白人(60.3%),平均年龄为55.3岁。持续高CPA组的参与者表现出较低的高血压和糖尿病发病率。多元线性回归分析显示,与持续低cpa组相比,持续高cpa组和高cpa、高arvpa组左室舒张末期尺寸指数升高,高cpa、高arvpa组左室质量指数和左房容积指数升高。结论:我们的研究表明,高CPA,即使伴随着PA水平的高变异性,也与中年左室结构的改变有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Estimated Physical Activity Patterns From Youth to Middle Age and Left Ventricular Structure and Function: A 30-Year Longitudinal Study.

Background: The long-term effects of physical activity (PA) variability and cumulative PA (CPA) from young adulthood on cardiac remodeling remain controversial, and it is unclear whether these effects resemble those observed in elite athletes.

Methods: A total of 1465 participants with recorded PA spanning a 30-year period were included in this study. PA levels were assessed at 9 follow-up visits using the CARDIA (Coronary Artery Risk Development in Young Adults) questionnaire. At year 30, left ventricular structure and function were evaluated using standardized echocardiography. CPA was calculated as the sum of average PA levels between consecutive visits multiplied by the corresponding intervisit intervals (in years). PA variability was quantified using average real variability (ARVPA). Additionally, participants were categorized into 4 groups: sustained low CPA and ARVPA group, low CPA and high ARVPA group, high CPA and low ARVPA group, and high CPA and high ARVPA group.

Results: This study included 849 women (57.1%), 883 White participants (60.3%), and had a mean age of 55.3 years. Participants in the sustained high CPA group exhibited lower incidence of hypertension and diabetes. Multiple linear regression analyses showed that, compared with the sustained-low-CPA group, the sustained-high-CPA group and high-CPA and high-ARVPA group exhibited increased left ventricular end-diastolic dimension index, and the high-CPA and high-ARVPA group revealed an increased left ventricular mass index and left atrial volume index.

Conclusions: Our study suggests that high CPA, even when accompanied with high variability in PA levels, is associated with alterations in left ventricular structure in midlife.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of the American Heart Association
Journal of the American Heart Association CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
9.40
自引率
1.90%
发文量
1749
审稿时长
12 weeks
期刊介绍: As an Open Access journal, JAHA - Journal of the American Heart Association is rapidly and freely available, accelerating the translation of strong science into effective practice. JAHA is an authoritative, peer-reviewed Open Access journal focusing on cardiovascular and cerebrovascular disease. JAHA provides a global forum for basic and clinical research and timely reviews on cardiovascular disease and stroke. As an Open Access journal, its content is free on publication to read, download, and share, accelerating the translation of strong science into effective practice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信