{"title":"晚期非小细胞肺癌患者预处理情绪困扰与生存结局之间的关系：7项试验中4632例患者的个体数据荟萃分析","authors":"Xin Li, Qisha Li, Su-Han Jin, Xiaofei Chen, Juanyan Shen, Hu Ma, Jian-Guo Zhou","doi":"10.1177/17588359251371826","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Emotional distress (ED) is associated with worse survival outcomes in patients with melanoma and non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). However, several preclinical studies suggest the association between stress and cancer treatment extends beyond ICIs alone.</p><p><strong>Objectives: </strong>To systematically evaluate the relationship between ED and NSCLC patient prognosis.</p><p><strong>Design: </strong>This study is an individual patient data (IPD) meta-analysis.</p><p><strong>Data sources and methods: </strong>Relevant studies were identified from the PubMed, Web of Science, The Cochrane Library, Embase, and Vivli databases to obtain IPD up to February 2025. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the association between ED and patient prognosis. Subgroup analysis was conducted based on patient treatment methods.</p><p><strong>Results: </strong>Kaplan-Meier analysis shows that compared with patients without ED, patients with ED had worse survival outcomes, regardless of ICIs or chemotherapy (CT) (HR of overall survival (OS), 1.21 (1.11-1.33), p = 0.01; hazard ratio of progression-free survival (PFS), 1.19 (1.07-1.31), p = 0.01). IPD meta-analysis also supported results above (HR of OS, 1.18, 95% CI, 1.07-1.30; HR of PFS, 1.15, 95% CI, 1.03-1.28).</p><p><strong>Conclusion: </strong>Our research suggests that ED is only a prognostic biomarker in NSCLC, rather than a predictive biomarker for ICIs.</p>","PeriodicalId":23053,"journal":{"name":"Therapeutic Advances in Medical Oncology","volume":"17 ","pages":"17588359251371826"},"PeriodicalIF":4.2000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441296/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between pretreatment emotional distress and survival outcomes in patients with advanced non-small-cell lung cancer: an individual patient data meta-analysis of 4632 patients in seven trials.\",\"authors\":\"Xin Li, Qisha Li, Su-Han Jin, Xiaofei Chen, Juanyan Shen, Hu Ma, Jian-Guo Zhou\",\"doi\":\"10.1177/17588359251371826\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Emotional distress (ED) is associated with worse survival outcomes in patients with melanoma and non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). However, several preclinical studies suggest the association between stress and cancer treatment extends beyond ICIs alone.</p><p><strong>Objectives: </strong>To systematically evaluate the relationship between ED and NSCLC patient prognosis.</p><p><strong>Design: </strong>This study is an individual patient data (IPD) meta-analysis.</p><p><strong>Data sources and methods: </strong>Relevant studies were identified from the PubMed, Web of Science, The Cochrane Library, Embase, and Vivli databases to obtain IPD up to February 2025. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the association between ED and patient prognosis. Subgroup analysis was conducted based on patient treatment methods.</p><p><strong>Results: </strong>Kaplan-Meier analysis shows that compared with patients without ED, patients with ED had worse survival outcomes, regardless of ICIs or chemotherapy (CT) (HR of overall survival (OS), 1.21 (1.11-1.33), p = 0.01; hazard ratio of progression-free survival (PFS), 1.19 (1.07-1.31), p = 0.01). IPD meta-analysis also supported results above (HR of OS, 1.18, 95% CI, 1.07-1.30; HR of PFS, 1.15, 95% CI, 1.03-1.28).</p><p><strong>Conclusion: </strong>Our research suggests that ED is only a prognostic biomarker in NSCLC, rather than a predictive biomarker for ICIs.</p>\",\"PeriodicalId\":23053,\"journal\":{\"name\":\"Therapeutic Advances in Medical Oncology\",\"volume\":\"17 \",\"pages\":\"17588359251371826\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441296/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Medical Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/17588359251371826\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Medical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/17588359251371826","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Association between pretreatment emotional distress and survival outcomes in patients with advanced non-small-cell lung cancer: an individual patient data meta-analysis of 4632 patients in seven trials.
Background: Emotional distress (ED) is associated with worse survival outcomes in patients with melanoma and non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). However, several preclinical studies suggest the association between stress and cancer treatment extends beyond ICIs alone.
Objectives: To systematically evaluate the relationship between ED and NSCLC patient prognosis.
Design: This study is an individual patient data (IPD) meta-analysis.
Data sources and methods: Relevant studies were identified from the PubMed, Web of Science, The Cochrane Library, Embase, and Vivli databases to obtain IPD up to February 2025. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the association between ED and patient prognosis. Subgroup analysis was conducted based on patient treatment methods.
Results: Kaplan-Meier analysis shows that compared with patients without ED, patients with ED had worse survival outcomes, regardless of ICIs or chemotherapy (CT) (HR of overall survival (OS), 1.21 (1.11-1.33), p = 0.01; hazard ratio of progression-free survival (PFS), 1.19 (1.07-1.31), p = 0.01). IPD meta-analysis also supported results above (HR of OS, 1.18, 95% CI, 1.07-1.30; HR of PFS, 1.15, 95% CI, 1.03-1.28).
Conclusion: Our research suggests that ED is only a prognostic biomarker in NSCLC, rather than a predictive biomarker for ICIs.
期刊介绍：
Therapeutic Advances in Medical Oncology is an open access, peer-reviewed journal delivering the highest quality articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of cancer. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in medical oncology, providing a forum in print and online for publishing the highest quality articles in this area. This journal is a member of the Committee on Publication Ethics (COPE).
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