多巴胺相关性状的个体差异影响多巴胺d2拮抗剂和抗抑郁药治疗预期的情绪效应。

IF 3.7 2区 医学 Q1 CLINICAL NEUROLOGY
Li-Ching Chuang, Nick Augustat, Philipp Bierwirth, Ty Lees, Diego A Pizzagalli, Dominik Endres, Erik M Mueller
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引用次数: 0

摘要

背景:高特质快感缺乏和低特质外向性不仅与低状态积极情绪有关,还与抑郁症、奖励加工中断和中脑边缘多巴胺能信号传导改变有关。对安慰剂反应的研究表明,治疗预期可能会改变多巴胺信号,提升积极影响,并减轻快感缺乏个体的抑郁症状。然而,目前尚不清楚这种抗抑郁安慰剂反应是否依赖于高快感缺乏症和低外向性中假定的低基线多巴胺能功能。本研究探讨了这些特征的个体间差异如何在多巴胺和治疗期望的操纵下影响积极的情感反应。材料和方法:在随机双盲2×2设计(N = 297)中,我们给予安慰剂或多巴胺D2受体拮抗剂舒匹利(400毫克),并通过告诉参与者他们接受的是情绪提升药物或非活性物质来操纵治疗预期。此外,我们评估了特质性快感缺乏症和外向性,并让参与者在治疗前后的6个不同时间点评估他们的状态积极影响。结果:特质性快感缺乏和外向性,以及一个广泛的特质性积极情感因子,在不同的时间点上预测状态的积极情感。重要的是,舒必利和抗抑郁药物治疗预期对积极情绪的影响受到多巴胺能特征的调节,例如舒必利在高快感缺乏症中增加了状态积极情绪,而在低快感缺乏症中减少了状态积极情绪。同样,抗抑郁治疗预期在低外向性中提高了积极影响,但在高外向性中降低了积极影响。结论:本研究表明,多巴胺相关的个体差异调节了舒必利和安慰剂干预对积极情感状态的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Individual differences in dopamine-related traits influence mood effects of dopamine D2-antagonist and antidepressant treatment expectations.

Background: High trait anhedonia and low trait extraversion have both been previously related to not only low state positive affect but also depressive disorders, disrupted reward processing, and altered mesolimbic dopaminergic signaling. Research on placebo responses suggests that treatment expectations may alter dopamine signaling, elevate positive affect, and reduce depressive symptoms in anhedonic individuals. However, it remains unclear whether such antidepressant placebo responses depend on putative low baseline dopaminergic functioning in high anhedonia and low extraversion. The present study investigates how interindividual differences in these traits influence positive affective responses under manipulation of dopamine and treatment expectations.

Materials and methods: In a randomized, double-blind 2×2 design (N = 297), we administered either placebo or the dopamine D2 receptor antagonist sulpiride (400 mg), and manipulated treatment expectations by telling participants that they received either a mood-elevating drug or an inactive substance. Moreover, we assessed trait anhedonia and extraversion, and had participants rate their state positive affect at 6 different time points before and after treatment.

Results: Trait anhedonia and extraversion, as well as a broad trait positive affectivity factor, predicted state positive affect across time points. Importantly, effects of sulpiride and antidepressant treatment expectations on positive affect were moderated by dopaminergic traits such that sulpiride increased state positive affect in high anhedonia but decreased it in low anhedonia. Similarly, antidepressant treatment expectations raised positive affect in low extraversion but reduced it in high extraversion.

Conclusions: This study demonstrates that dopamine-related individual differences moderate the effects of both sulpiride and a placebo intervention on positive affective state.

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来源期刊
CiteScore
8.40
自引率
2.10%
发文量
230
审稿时长
4-8 weeks
期刊介绍: The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.
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