特发性颅内高压患者心脑血管疾病的患病率。

IF 1.6 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2025-09-12 DOI:10.1016/j.clineuro.2025.109158

Ilene Trinh , Jacqueline K. Shaia , David Kaelber , Rishi P. Singh , Katherine E. Talcott , Devon A. Cohen

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引用次数: 0

摘要

背景和目的：特发性颅内高压（IIH）是一种神经代谢性疾病，可导致衰弱性视力丧失和头痛，并与肥胖相关。最近的研究表明，IIH患者患心血管疾病的风险增加，尽管数据很少。本研究的目的是调查IIH患者的心脑血管事件发生率及相关危险因素。方法：采用由美国70家医疗机构组成的大型综合多中心研究平台（TriNetX）进行横断面研究，涉及超过1.15亿患者。计算并比较IIH组和两个对照组（普通人群和高体重指数（BMI≥30 kg/m2）患者）的发病率，包括脑血管疾病（CVD）、心肌梗死、心力衰竭、原发性高血压（HTN）和II型糖尿病（DM）。使用卡方双侧检验来比较p值为：结果：IIH患者的CVD患病率为7.13 %，而总人口为3.13 %，高BMI对照组为5.47 % （p ）讨论：在美国，与普通人群和肥胖人群相比，≤ 60岁的IIH患者的CVD和HTN患病率明显更高。因此，我们建议在IIH背景下对这些发病率进行早期筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prevalence of cardiovascular and cerebrovascular disease in idiopathic intracranial hypertension

Background and objectives

Idiopathic intracranial hypertension (IIH) is a neurometabolic disease that can cause debilitating vision loss and headaches, and is associated with obesity. Recent studies have suggested an increased risk of cardiovascular disease in patients with IIH, although data is scarce. The objective of this study was to investigate the prevalence of cardiovascular and cerebrovascular events and associated risk factors in patients with IIH.

Methods

A cross-sectional study was conducted using a large aggregate multicenter research platform (TriNetX) consisting of 70 healthcare organizations in the United States with over 115 million patients. Prevalence of outcomes including cerebrovascular disease (CVD), myocardial infarction, heart failure, essential hypertension (HTN), and type II diabetes mellitus (DM) were calculated and compared between the IIH group and two controls: the general population and patients with high body mass index (BMI ≥ 30 kg/m²). Chi Square two-sided tests were used to compare groups where a p-value of < 0.01 was deemed significant. Prevalence odds ratios (OR) were performed and 95 % confidence intervals calculated.

Results

CVD prevalence was 7.13 % in IIH patients compared to 3.13 % in the total population and 5.47 % in high BMI controls (p < 0.0001). With age stratification, CVD rates were higher in IIH patients at ages 0–70 compared to the total population and high BMI patients (p < 0.0001). IIH patients had 2.38 times increased odds of having CVD compared to the total population (95 % CI, 2.26–2.50) and 1.33 times increased odds compared to high BMI patients (95 % CI 1.26–1.40). Prevalence of HTN was 23.1 % in IIH patients, which was higher compared to the total population (14.48 %) and lower compared to high BMI controls (35.66 %) (p < 0.0001). However, HTN rates were higher in IIH patients at earlier ages (0−60) (p < 0.0001). Compared to high BMI controls, IIH had decreased odds of DM and myocardial infarction (p < 0.01).

Discussion

Patients with IIH had significantly higher rates of CVD and HTN in patients ≤ 60 years of age compared to the general and obesity populations in the United States. Therefore, we recommend early screening for these morbidities in the setting of IIH.

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.