Comparative performance of logistic regression, multilayer perceptron and decision tree models for predicting surgical pressure injuries: a retrospective cohort study.

Objectives: Surgical pressure injuries (SPIs) are a significant patient safety risk due to prolonged immobility and tissue hypoperfusion under general anaesthesia. Existing risk assessment tools lack real-time predictive capabilities. This study developed and validated a machine-learning model for SPI prediction and clinical integration.

Method: This retrospective cohort study analysed electronic health records from 931 surgical inpatients under general anaesthesia between January 2016 and December 2021. SPI cases were identified using ICD-10 codes with 1:1 matching by medical specialty. Data preprocessing included imputation, normalisation and outlier removal. Logistic regression (LR), multilayer perceptron (MLP) and decision tree (DT) models were developed and validated via cross-validation. Model performance was assessed using area under the curve (AUC), accuracy, precision, recall and F1 score.

Results: Significant SPI predictors included the Charlson Comorbidity Index (p<0.001), number of medication types (p=0.001) and body mass index (p<0.001). The MLP outperformed LR (AUC=0.707) and DT (AUC=0.717), achieving the highest AUC (0.836), accuracy (0.773), precision (0.812), recall (0.688) and F1 score (0.745).

Discussion: The MLP model effectively identified key SPI risk factors, outperforming LR and DT by capturing non-linear relationships. Its integration into clinical workflows may enhance perioperative risk management through early detection and targeted interventions.

Conclusion: Machine learning integration can improve early SPI detection and personalised prevention. The MLP model demonstrated the highest potential for real-time SPI risk stratification. Future research should validate this model across diverse surgical populations and develop scalable strategies for clinical implementation.