Hannah Oh, Lusine Yaghjyan, Yujing J Heng, Gabrielle M Baker, Brian R Sardella, Matt B Mahoney, Divya Murthy, Bernard Rosner, Rulla M Tamimi
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Linear regression was conducted to estimate the associations of anthropometric measures with stem cell marker expression, adjusting for potential confounders.</p><p><strong>Results: </strong>BMI at age 18 (≥23.0 vs. <19.0 kg/m<sup>2</sup>), BMI at benign breast biopsy (≥30.0 vs. <21.0 kg/m<sup>2</sup>), and change in BMI since age 18 (>7.0 vs. ≤0 kg/m<sup>2</sup>) were inversely associated with CD44 expression levels in epithelium and stroma combined (β [95% CI]= -0.30 [-0.55, -0.04]; -0.34 [-0.59, -0.08]; -0.38 [-0.65, -0.10]; respectively). Change in BMI since age 18 (>7.0 vs. ≤0 kg/m<sup>2</sup>) was also inversely associated with ALDH1A1 expression in epithelium (-0.31 [-0.62, -0.001]) and stroma (-0.63 [-1.18, -0.08]). Birthweight and height were not associated.</p><p><strong>Conclusion: </strong>Adiposity measures may be associated with stem cell marker expression among cancer-free women.</p>","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516083/pdf/","citationCount":"0","resultStr":"{\"title\":\"Birthweight, height, and body mass index in relation to the expression of stem cell markers among women with benign breast biopsies in the Nurses' Health Study II.\",\"authors\":\"Hannah Oh, Lusine Yaghjyan, Yujing J Heng, Gabrielle M Baker, Brian R Sardella, Matt B Mahoney, Divya Murthy, Bernard Rosner, Rulla M Tamimi\",\"doi\":\"10.1038/s41416-025-03194-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The amount and activity of breast stem cell population may play an important role in breast carcinogenesis. 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引用次数: 0
摘要
背景：乳腺干细胞群的数量和活性可能在乳腺癌发生中起重要作用。然而，关于早期生活和成年人体测量指标，包括体重指数（BMI）、出生体重和身高，是否与非癌性乳腺组织中的干细胞标志物表达相关，我们知之甚少。方法：在护士健康研究II中，对730例活检证实的乳腺良性疾病（BBD）的女性进行定量免疫组化染色，检测组织病理学正常的乳腺上皮和间质组织中干细胞标志物（CD44, CD24, ALDH1A1）。进行线性回归来估计人体测量测量与干细胞标记物表达的关联，并对潜在的混杂因素进行调整。结果：18岁时BMI（≥23.0 vs. 2）、乳腺良性活检时BMI（≥30.0 vs. 2）、18岁后BMI变化（bbb7.0 vs.≤0 kg/m2）与上皮和间质CD44表达水平呈负相关（β [95% CI]分别= -0.30[-0.55,-0.04]、-0.34[-0.59,-0.08]、-0.38[-0.65,-0.10]）。18岁以后的BMI变化（BMI 7.0 vs≤0 kg/m2）也与ALDH1A1在上皮（-0.31[-0.62,-0.001]）和间质（-0.63[-1.18,-0.08]）中的表达呈负相关。出生体重和身高没有关联。结论：在无癌女性中，肥胖措施可能与干细胞标志物表达有关。
Birthweight, height, and body mass index in relation to the expression of stem cell markers among women with benign breast biopsies in the Nurses' Health Study II.
Background: The amount and activity of breast stem cell population may play an important role in breast carcinogenesis. However, little is known about whether early-life and adult anthropometric measures, including body mass index (BMI), birthweight, and height, are associated with stem cell marker expressions in non-cancerous breast tissue.
Methods: Among 730 women with biopsy-confirmed benign breast disease (BBD) in the Nurses' Health Study II, we quantified immunohistochemical staining of stem cell markers (CD44, CD24, ALDH1A1) in histopathologically normal epithelial and stromal breast tissue. Linear regression was conducted to estimate the associations of anthropometric measures with stem cell marker expression, adjusting for potential confounders.
Results: BMI at age 18 (≥23.0 vs. <19.0 kg/m2), BMI at benign breast biopsy (≥30.0 vs. <21.0 kg/m2), and change in BMI since age 18 (>7.0 vs. ≤0 kg/m2) were inversely associated with CD44 expression levels in epithelium and stroma combined (β [95% CI]= -0.30 [-0.55, -0.04]; -0.34 [-0.59, -0.08]; -0.38 [-0.65, -0.10]; respectively). Change in BMI since age 18 (>7.0 vs. ≤0 kg/m2) was also inversely associated with ALDH1A1 expression in epithelium (-0.31 [-0.62, -0.001]) and stroma (-0.63 [-1.18, -0.08]). Birthweight and height were not associated.
Conclusion: Adiposity measures may be associated with stem cell marker expression among cancer-free women.
期刊介绍：
The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.
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