Masoud Ojarudi, Ali Golchin, Hamid Reza Karamdel, Mohammad Valilo, Parviz Ranjbarvan
{"title":"榆果提取物对ccl4诱导的大鼠肝脏氧化应激和炎症的保护作用。","authors":"Masoud Ojarudi, Ali Golchin, Hamid Reza Karamdel, Mohammad Valilo, Parviz Ranjbarvan","doi":"10.22038/ajp.2025.25915","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess <i>Elaeagnus angustifolia</i> L. fruit extract's potential in shielding rat livers from CCl<sub>4</sub> damage.</p><p><strong>Materials and methods: </strong>30 Male Wistar rats were randomly divided into five groups: normal control (received distilled water), <i>E. angustifolia</i> hydroalcoholic extract control, CCl<sub>4</sub> control, <i>E. angustifolia</i> extract pretreatment (600 mg/kg), and silymarin pretreatment (100 mg/kg). After 14 days of oral administration of extracts, CCl<sub>4</sub> was injected intraperitoneally. The samples were collected 48 hr later. Histological and biochemical analyses were then carried out.</p><p><strong>Results: </strong>CCl<sub>4</sub> injection caused significant (p<0.001) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. <i>E</i> <i>.</i> <i>angustifolia</i> extract pre-treatment significantly (p<0.05) returned changes to the normal state.</p><p><strong>Conclusion: </strong>This study's findings revealed that <i>E. angustifolia</i> extract pretreatment could reduce liver injury caused by CCl<sub>4</sub> in rats.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 5","pages":"1519-1530"},"PeriodicalIF":2.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441200/pdf/","citationCount":"0","resultStr":"{\"title\":\"Protective effects of <i>Elaeagnus angustifolia</i> L. fruit extract on CCl<sub>4</sub>-induced oxidative stress and inflammation in rats liver.\",\"authors\":\"Masoud Ojarudi, Ali Golchin, Hamid Reza Karamdel, Mohammad Valilo, Parviz Ranjbarvan\",\"doi\":\"10.22038/ajp.2025.25915\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess <i>Elaeagnus angustifolia</i> L. fruit extract's potential in shielding rat livers from CCl<sub>4</sub> damage.</p><p><strong>Materials and methods: </strong>30 Male Wistar rats were randomly divided into five groups: normal control (received distilled water), <i>E. angustifolia</i> hydroalcoholic extract control, CCl<sub>4</sub> control, <i>E. angustifolia</i> extract pretreatment (600 mg/kg), and silymarin pretreatment (100 mg/kg). After 14 days of oral administration of extracts, CCl<sub>4</sub> was injected intraperitoneally. The samples were collected 48 hr later. Histological and biochemical analyses were then carried out.</p><p><strong>Results: </strong>CCl<sub>4</sub> injection caused significant (p<0.001) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. <i>E</i> <i>.</i> <i>angustifolia</i> extract pre-treatment significantly (p<0.05) returned changes to the normal state.</p><p><strong>Conclusion: </strong>This study's findings revealed that <i>E. angustifolia</i> extract pretreatment could reduce liver injury caused by CCl<sub>4</sub> in rats.</p>\",\"PeriodicalId\":8677,\"journal\":{\"name\":\"Avicenna Journal of Phytomedicine\",\"volume\":\"15 5\",\"pages\":\"1519-1530\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441200/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Avicenna Journal of Phytomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/ajp.2025.25915\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avicenna Journal of Phytomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/ajp.2025.25915","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver.
Objective: Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess Elaeagnus angustifolia L. fruit extract's potential in shielding rat livers from CCl4 damage.
Materials and methods: 30 Male Wistar rats were randomly divided into five groups: normal control (received distilled water), E. angustifolia hydroalcoholic extract control, CCl4 control, E. angustifolia extract pretreatment (600 mg/kg), and silymarin pretreatment (100 mg/kg). After 14 days of oral administration of extracts, CCl4 was injected intraperitoneally. The samples were collected 48 hr later. Histological and biochemical analyses were then carried out.
Results: CCl4 injection caused significant (p<0.001) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. E.angustifolia extract pre-treatment significantly (p<0.05) returned changes to the normal state.
Conclusion: This study's findings revealed that E. angustifolia extract pretreatment could reduce liver injury caused by CCl4 in rats.
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