{"title":"评价EC-SERS和EC-SOERS检测烟酸：高氯环境中表面电位的影响","authors":"Claire M. Cullinan, and , Christa L. Brosseau*, ","doi":"10.1021/acs.jpcc.5c05385","DOIUrl":null,"url":null,"abstract":"<p >Nicotinic acid serves as an important biomarker for type 2 diabetes mellitus (T2DM) and can be detected in human tear fluid. Tear fluid monitoring presents a promising noninvasive alternative for diabetes monitoring. Evaluating nicotinic acid levels in tear fluid during the prediabetic stage could help initiate intervention and preventive treatment before the clinical onset of T2DM. This paper reports on the effectiveness of electrochemical surface-enhanced Raman spectroscopy (EC-SERS) and electrochemical surface oxidation-enhanced Raman spectroscopy (EC-SOERS) methods for the detection of nicotinic acid in artificial tear fluid. EC-SERS analysis of nicotinic acid was deemed unsuccessful due to chloride interference in the tear fluid. EC-SOERS analysis of nicotinic acid was able to successfully detect characteristic peaks in artificial tear fluid with better sensitivity than EC-SERS. These results highlight the potential of EC-SOERS for noninvasive point-of-care detection of T2DM.</p>","PeriodicalId":61,"journal":{"name":"The Journal of Physical Chemistry C","volume":"129 39","pages":"17662–17668"},"PeriodicalIF":3.2000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluating EC-SERS and EC-SOERS for Nicotinic Acid Detection: The Influence of Surface Potential in High-Chloride Environments\",\"authors\":\"Claire M. Cullinan, and , Christa L. Brosseau*, \",\"doi\":\"10.1021/acs.jpcc.5c05385\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Nicotinic acid serves as an important biomarker for type 2 diabetes mellitus (T2DM) and can be detected in human tear fluid. Tear fluid monitoring presents a promising noninvasive alternative for diabetes monitoring. Evaluating nicotinic acid levels in tear fluid during the prediabetic stage could help initiate intervention and preventive treatment before the clinical onset of T2DM. This paper reports on the effectiveness of electrochemical surface-enhanced Raman spectroscopy (EC-SERS) and electrochemical surface oxidation-enhanced Raman spectroscopy (EC-SOERS) methods for the detection of nicotinic acid in artificial tear fluid. EC-SERS analysis of nicotinic acid was deemed unsuccessful due to chloride interference in the tear fluid. EC-SOERS analysis of nicotinic acid was able to successfully detect characteristic peaks in artificial tear fluid with better sensitivity than EC-SERS. These results highlight the potential of EC-SOERS for noninvasive point-of-care detection of T2DM.</p>\",\"PeriodicalId\":61,\"journal\":{\"name\":\"The Journal of Physical Chemistry C\",\"volume\":\"129 39\",\"pages\":\"17662–17668\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Physical Chemistry C\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jpcc.5c05385\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Physical Chemistry C","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jpcc.5c05385","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Evaluating EC-SERS and EC-SOERS for Nicotinic Acid Detection: The Influence of Surface Potential in High-Chloride Environments
Nicotinic acid serves as an important biomarker for type 2 diabetes mellitus (T2DM) and can be detected in human tear fluid. Tear fluid monitoring presents a promising noninvasive alternative for diabetes monitoring. Evaluating nicotinic acid levels in tear fluid during the prediabetic stage could help initiate intervention and preventive treatment before the clinical onset of T2DM. This paper reports on the effectiveness of electrochemical surface-enhanced Raman spectroscopy (EC-SERS) and electrochemical surface oxidation-enhanced Raman spectroscopy (EC-SOERS) methods for the detection of nicotinic acid in artificial tear fluid. EC-SERS analysis of nicotinic acid was deemed unsuccessful due to chloride interference in the tear fluid. EC-SOERS analysis of nicotinic acid was able to successfully detect characteristic peaks in artificial tear fluid with better sensitivity than EC-SERS. These results highlight the potential of EC-SOERS for noninvasive point-of-care detection of T2DM.
期刊介绍：
The Journal of Physical Chemistry A/B/C is devoted to reporting new and original experimental and theoretical basic research of interest to physical chemists, biophysical chemists, and chemical physicists.
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