褐色脂肪组织成像:现状与未来展望。

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-08-16 eCollection Date: 2025-01-01 DOI:10.7150/thno.111643
Junhao Li, Li Wang, Shiyao Wu, Guifen Yang, Long Jiang Zhang
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引用次数: 0

摘要

棕色脂肪组织(BAT)是一种特殊类型的脂肪组织,利用多种营养物质,被认为是代谢、疾病、心血管疾病和某些类型癌症的新治疗靶点。然而,目前BAT的标准成像方法,18F-氟脱氧葡萄糖正电子发射断层扫描计算机断层扫描([18F] FDG PET-CT),由于其高昂的成本,长时间的成像和辐射暴露,不能满足临床需求,这是纵向研究的重要问题。为了克服这些限制,人们正在探索新兴的成像模式,旨在通过关注BAT的替代生物标志物(如脂质含量、灌注、密度、热排放和线粒体活性)来解决这些挑战。先进的成像方法已发展为成像精确,操作方便,广泛的适用性。在这篇综述中,我们简要介绍了BAT的生理和功能,以及BAT成像方法的最新进展,包括正电子发射断层扫描、单光子发射计算机断层扫描、磁共振成像、计算机断层扫描、红外热成像、光声成像和氙增强成像。未来的前景,如人工智能在BAT成像中的应用,也进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Imaging Brown Adipose Tissue: Current State and Future Perspective.

Imaging Brown Adipose Tissue: Current State and Future Perspective.

Imaging Brown Adipose Tissue: Current State and Future Perspective.

Imaging Brown Adipose Tissue: Current State and Future Perspective.

Brown adipose tissue (BAT) is a specialized type of fat tissue that utilizes various nutrients and is considered a novel therapeutic target for metabolic, disorders, cardiovascular diseases, and certain types of cancer. However, the current standard imaging method for BAT, 18F-flurodeoxyglucose positron emission tomography computed tomography ([18F] FDG PET-CT), fails to meet clinical demands due to its prohibitive costs, prolonged imaging times, and radiation exposure, which are significant concerns for longitudinal studies. To overcome these limitations, emerging imaging modalities are being explored, aiming to address these challenges by focusing on alternative biomarkers of BAT, such as lipid content, perfusion, density, thermal emissions, and mitochondrial activity. Advanced imaging methods have been developed for precise imaging, facile operation, and broad applicability. In this review, we provide a brief overview of BAT physiology and function, as well as current advancements in BAT imaging methods, including positron emission tomography, single photon emission computed tomography, magnetic resonance imaging, computed tomography, infrared thermography, optoacoustic imaging, and Xenon-enhanced imaging. Future perspectives, such as the application of artificial intelligence to BAT imaging, are also discussed.

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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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