Nour El Ghazal, Graziella Galvao Goncalves, Muhammad A Jawad, Michael L Kendrick, Andre F Teixeira, Omar M Ghanem
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Chi-squared tests, t-tests for parametric data and Mann Whitney U tests for nonparametric data, and a linear fixed effects model were used for statistical analysis.</p><p><strong>Results: </strong>101 patients underwent BPD/DS and 32 underwent SADI-S between 2008 and 2014. Mean preoperative body mass index (57.5 ± 9.5 kg/m<sup>2</sup> in BPD/DS vs 59.9 ± 9.7 kg/m<sup>2</sup> in SADI-S, p = 0.208) and age (46.9 ± 11.0 years in BPD/DS vs 43.3 ± 11.3 years in SADI-S, p = 0.102) were comparable between both groups. The mean percentage total weight loss (%TWL) at all time points, the maximum % TWL (45.7 ± 9.6% in BPD/DS vs 47.3 ± 10.1% in SADI-S, p = 0.418), and remission rates of obesity-related medical conditions were similar. The SADI-S group experienced more intraoperative complications (n = 3 vs n = 0 in BPD/DS, p = 0.013) and longer hospital length of stay (4 vs 3 days in BPD/DS, p < 0.001). More nutritional complications were seen after BPD/DS (53.5% vs 15.6% in SADI-S, p < 0.001). Rates of early and late complications were comparable between both cohorts.</p><p><strong>Conclusions: </strong>Although SADI-S is a relatively newer technique, long-term results seem promising, especially when compared to the traditional DS, which is known to raise safety and nutritional concerns. More long-term comparative studies are needed to contribute to this growing data.</p>","PeriodicalId":22174,"journal":{"name":"Surgical Endoscopy And Other Interventional Techniques","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term 10-year outcomes of biliopancreatic diversion with duodenal switch (BPD/DS) and single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S): a comparative multicenter cohort study.\",\"authors\":\"Nour El Ghazal, Graziella Galvao Goncalves, Muhammad A Jawad, Michael L Kendrick, Andre F Teixeira, Omar M Ghanem\",\"doi\":\"10.1007/s00464-025-12170-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>With the recent endorsement of the single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) as a modification of the biliopancreatic diversion with duodenal switch (BPD/DS), long-term data regarding their comparison is scarce. This study aimed to compare the 10-year efficacy and safety outcomes of BPD/DS and SADI-S.</p><p><strong>Methods: </strong>A retrospective review of patients undergoing BPD/DS and SADI-S as primary procedures was conducted at two centers. Outcomes assessed were weight loss, remission of obesity-related medical conditions and early and late complications. Chi-squared tests, t-tests for parametric data and Mann Whitney U tests for nonparametric data, and a linear fixed effects model were used for statistical analysis.</p><p><strong>Results: </strong>101 patients underwent BPD/DS and 32 underwent SADI-S between 2008 and 2014. Mean preoperative body mass index (57.5 ± 9.5 kg/m<sup>2</sup> in BPD/DS vs 59.9 ± 9.7 kg/m<sup>2</sup> in SADI-S, p = 0.208) and age (46.9 ± 11.0 years in BPD/DS vs 43.3 ± 11.3 years in SADI-S, p = 0.102) were comparable between both groups. The mean percentage total weight loss (%TWL) at all time points, the maximum % TWL (45.7 ± 9.6% in BPD/DS vs 47.3 ± 10.1% in SADI-S, p = 0.418), and remission rates of obesity-related medical conditions were similar. The SADI-S group experienced more intraoperative complications (n = 3 vs n = 0 in BPD/DS, p = 0.013) and longer hospital length of stay (4 vs 3 days in BPD/DS, p < 0.001). More nutritional complications were seen after BPD/DS (53.5% vs 15.6% in SADI-S, p < 0.001). Rates of early and late complications were comparable between both cohorts.</p><p><strong>Conclusions: </strong>Although SADI-S is a relatively newer technique, long-term results seem promising, especially when compared to the traditional DS, which is known to raise safety and nutritional concerns. 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引用次数: 0
摘要
背景：近年来，单吻合术十二指肠回肠旁路与套筒胃切除术（SADI-S）被认可为十二指肠开关胆胰分流术（BPD/DS）的改进，但关于两者比较的长期数据很少。本研究旨在比较BPD/DS和SADI-S的10年疗效和安全性结果。方法：回顾性分析两个中心接受BPD/DS和SADI-S作为主要手术的患者。评估的结果是体重减轻、肥胖相关疾病的缓解以及早期和晚期并发症。参数数据采用卡方检验、t检验，非参数数据采用Mann Whitney U检验，统计分析采用线性固定效应模型。结果：2008 - 2014年，101例患者接受BPD/DS治疗，32例患者接受SADI-S治疗。两组平均术前体重指数（BPD/DS组为57.5±9.5 kg/m2， SADI-S组为59.9±9.7 kg/m2, p = 0.208）和年龄（BPD/DS组为46.9±11.0岁，SADI-S组为43.3±11.3岁，p = 0.102）具有可比性。所有时间点的平均总体重减轻百分比（%TWL），最大%TWL （BPD/DS为45.7±9.6%，SADI-S为47.3±10.1%,p = 0.418）和肥胖相关疾病的缓解率相似。SADI-S组出现了更多的术中并发症（BPD/DS中n = 3 vs n = 0, p = 0.013）和更长的住院时间（BPD/DS中4 vs 3天，p）。结论：尽管SADI-S是一种相对较新的技术，但长期的结果似乎是有希望的，特别是与传统的DS相比，传统DS已知会提高安全性和营养问题。需要更多的长期比较研究来为这一不断增长的数据做出贡献。
Long-term 10-year outcomes of biliopancreatic diversion with duodenal switch (BPD/DS) and single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S): a comparative multicenter cohort study.
Background: With the recent endorsement of the single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) as a modification of the biliopancreatic diversion with duodenal switch (BPD/DS), long-term data regarding their comparison is scarce. This study aimed to compare the 10-year efficacy and safety outcomes of BPD/DS and SADI-S.
Methods: A retrospective review of patients undergoing BPD/DS and SADI-S as primary procedures was conducted at two centers. Outcomes assessed were weight loss, remission of obesity-related medical conditions and early and late complications. Chi-squared tests, t-tests for parametric data and Mann Whitney U tests for nonparametric data, and a linear fixed effects model were used for statistical analysis.
Results: 101 patients underwent BPD/DS and 32 underwent SADI-S between 2008 and 2014. Mean preoperative body mass index (57.5 ± 9.5 kg/m2 in BPD/DS vs 59.9 ± 9.7 kg/m2 in SADI-S, p = 0.208) and age (46.9 ± 11.0 years in BPD/DS vs 43.3 ± 11.3 years in SADI-S, p = 0.102) were comparable between both groups. The mean percentage total weight loss (%TWL) at all time points, the maximum % TWL (45.7 ± 9.6% in BPD/DS vs 47.3 ± 10.1% in SADI-S, p = 0.418), and remission rates of obesity-related medical conditions were similar. The SADI-S group experienced more intraoperative complications (n = 3 vs n = 0 in BPD/DS, p = 0.013) and longer hospital length of stay (4 vs 3 days in BPD/DS, p < 0.001). More nutritional complications were seen after BPD/DS (53.5% vs 15.6% in SADI-S, p < 0.001). Rates of early and late complications were comparable between both cohorts.
Conclusions: Although SADI-S is a relatively newer technique, long-term results seem promising, especially when compared to the traditional DS, which is known to raise safety and nutritional concerns. More long-term comparative studies are needed to contribute to this growing data.
期刊介绍：
Uniquely positioned at the interface between various medical and surgical disciplines, Surgical Endoscopy serves as a focal point for the international surgical community to exchange information on practice, theory, and research.
Topics covered in the journal include:
-Surgical aspects of:
Interventional endoscopy,
Ultrasound,
Other techniques in the fields of gastroenterology, obstetrics, gynecology, and urology,
-Gastroenterologic surgery
-Thoracic surgery
-Traumatic surgery
-Orthopedic surgery
-Pediatric surgery
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