液态金属镓制药公司。

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI:10.7150/thno.116184
Dawei Wang, Wei Xu, Yuxin Liu, Luying Chen, Ting He, Hong Tan, Shuting He, Jie Zhu, Caiting Wang, Zhongyang Yu, Chong Li, Weidong Pan, Wei Rao, Jing Liu
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引用次数: 0

摘要

常温液态金属镓作为一种历史悠久的多靶点药理活性金属元素,在医学领域,特别是在抗菌、抗炎、抗癌、成骨、放射药理学、分子成像等新兴药物类别中显示出巨大的潜力。然而,不同的结构和物理/化学成分,与生物体复杂的相互作用,以及不充分的机制解释,给镓基药物的临床翻译带来了严峻的挑战。本文系统地识别和描述了有前景的镓基药物,重点介绍了典型特征、基本药物活性、代表性药物配方和实际实施,旨在激发药物发现和进一步研究的创新概念。有意义的是,本文提出了镓基液态金属用于筛选药物配方的新见解,有望为提高活性药物成分(Ga(0)/Ga(III))的生物利用度、靶向性、生物相容性和药理功效带来更广泛的策略。此外,还概述了这些新兴镓基药物尚未解决的挑战和未来的展望,旨在为未来镓基药物的学术探索和转化医学提供帮助。总体而言,镓基药物具有丰富的药物配方和药物活性,为未来的制药工程开辟了广阔的领域和巨大的潜力,有望以一系列突破性的发现和开创性的技术迎来金属药物的划时代发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Liquid Metal Gallium Pharmaceuticals.

The room temperature liquid metal gallium, as a multi-targeted pharmacologically active metallic element with long historical investigation, has shown great potential in the field of medicine, especially in antibacterial, anti-inflammatory, anticancer, osteogenesis, radio-pharmacology, molecular imaging and more emerging drug categories. However, diverse structures and physical/chemical compositions, complex interactions with living organisms, and insufficient mechanism interpretation, pose serious challenges for the clinical translation of gallium-based pharmaceuticals. This review systematically identified and described promising gallium-based pharmaceuticals, with emphasis on typical features, fundamental pharmaceutical activities, representative pharmaceutical formulations, and practical implementations, aiming to inspire innovative concepts for drug discovery and further investigation. Meaningfully, new insights into gallium-based liquid metals for screening pharmaceutical formulations are presented, which promise to bring broader strategies for enhancing the bioavailability, targetability, biocompatibility and pharmacological efficacy of active pharmaceutical ingredients (Ga(0)/Ga(III)). Besides, the unresolved challenges and future perspectives of these emerging gallium-based pharmaceuticals were also outlined, aiming to aid for future academic explorations and translational medicine of gallium-based pharmaceuticals. Overall, gallium-based pharmaceuticals with tremendous pharmaceutical formulations and pharmaceutical activities open up a huge scope great potential for future pharmaceutical engineering, which are promising to usher epochal metallodrug development with a series of breakthrough discoveries and pioneering technologies.

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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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