磁环- mpi:基于动态环形梯度阵列的电控FFL-MPI系统设计。

IF 3.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Ziwei Chen, Zhongwei Bian, Jian'an Ye, Jie He, Yu An, Jie Tian
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引用次数: 0

摘要

目的:本研究旨在提出并验证一种新型的电控无场线(FFL)磁粒子成像(MPI)系统,以解决现有电子旋转FFL-MPI设计的几个方面,包括梯度增强的局限性、驱动系统的结构复杂性和线圈耦合效应。我们采用了一个动态环形磁场收敛梯度阵列(dRMGA),由多对电磁铁沿径向和轴向对称排列组成。这种配置确保生成的FFL磁场方向始终垂直于梯度方向和成像平面。层析成像仅使用一组与梯度线圈正交排列的驱动线圈。通过动态调制径向线圈对的电流相位,结合轴向线圈对的差动电流控制,实现了三维FFL扫描。此外,我们进行了电磁和图像重建仿真,以评估不同磁极对数量的磁配置下FFL的生成特性和重建性能。结果:仿真结果表明,所提出的系统可以实现高效稳定的FFL旋转和轴向平移,支持快速的三维层析扫描。此外,我们系统地分析了不同的极对配置如何影响生成的FFL质量和最终的图像分辨率。这些发现对磁极对缩放如何影响梯度强度、场均匀性和系统复杂性提供了具体的指导。意义:提出的MagRing-MPI系统增强了磁场梯度和成像质量,简化了驱动线圈配置以降低系统复杂性,并最大限度地减少了电磁耦合和馈通效应。这些改进为开发可扩展的高性能MPI系统提供了良好的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MagRing-MPI: design of electrically controlled FFL-MPI system based on a dynamic ring-shaped gradient array.

Objective: This study aims to propose and validate a novel electrically controlled field-free line (FFL) magnetic particle imaging (MPI) system to address several aspects of existing electronically rotated FFL-MPI designs, including limitations in gradient enhancement, structural complexity of the drive system, and coil coupling effects. Methods: We employ a dynamic ring-shaped magnetic-field-converging gradient array (dRMGA), consisting of multiple pairs of electromagnets symmetrically arranged along the radial and axial directions. This configuration ensures that the magnetic field direction of the generated FFL remains consistently perpendicular to both the gradient direction and the imaging plane. Tomographic imaging uses only one set of drive coils arranged orthogonally to the gradient coils. Three-dimensional FFL scanning is realized by dynamically modulating the current phase of the radial coil pairs in conjunction with differential current control of the axial coil pairs. In addition, we conduct electromagnetic and image reconstruction simulations to evaluate the FFL generation characteristics and reconstruction performance under magnetic configurations with different numbers of pole pairs. Results: Simulation results demonstrate that the proposed system can achieve efficient and stable FFL rotation and axial translation, supporting rapid 3D tomographic scanning. In addition, we systematically analyzed how different pole-pair configurations affect the quality of the generated FFL and the resulting image resolution. These findings offer concrete guidance on how pole-pair scaling influences gradient strength, field uniformity, and system complexity. Significance: The proposed MagRing-MPI system enhances magnetic field gradients and imaging quality, simplifies the drive-coil configuration to reduce system complexity, and minimizes electromagnetic coupling and feedthrough effects. These improvements provide a promising foundation for the development of scalable and high-performance MPI systems.

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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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