{"title":"氯氮平对精神分裂症患者免疫相关生物标志物的影响。","authors":"Jia Wei, Ting Dong","doi":"10.1002/jbt.70503","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Schizophrenia is a prevalent mental disorder that significantly impacts global health, with approximately 1% of the population affected and around 30% of cases classified as treatment-resistant schizophrenia (TRS). Clozapine is established as the gold standard for TRS management, yet its use is often complicated by potential adverse effects and the necessity for rigorous blood monitoring due to the risk of severe neutropenia. Recent studies have revealed that clozapine not only influences psychiatric symptoms but also alters immune system functioning and cytokine profiles in patients with schizophrenia. This interplay between clozapine treatment and immune-related biomarkers warrants deeper investigation to elucidate the underlying mechanisms of the disease and to refine therapeutic approaches. Identifying specific biomarkers could enhance clinical decision-making regarding the initiation of clozapine therapy, allowing for more tailored treatments and improved patient outcomes.</p></div>","PeriodicalId":15151,"journal":{"name":"Journal of Biochemical and Molecular Toxicology","volume":"39 9","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effect of Clozapine on Immune-Related Biomarkers in Schizophrenia Patients\",\"authors\":\"Jia Wei, Ting Dong\",\"doi\":\"10.1002/jbt.70503\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Schizophrenia is a prevalent mental disorder that significantly impacts global health, with approximately 1% of the population affected and around 30% of cases classified as treatment-resistant schizophrenia (TRS). Clozapine is established as the gold standard for TRS management, yet its use is often complicated by potential adverse effects and the necessity for rigorous blood monitoring due to the risk of severe neutropenia. Recent studies have revealed that clozapine not only influences psychiatric symptoms but also alters immune system functioning and cytokine profiles in patients with schizophrenia. This interplay between clozapine treatment and immune-related biomarkers warrants deeper investigation to elucidate the underlying mechanisms of the disease and to refine therapeutic approaches. Identifying specific biomarkers could enhance clinical decision-making regarding the initiation of clozapine therapy, allowing for more tailored treatments and improved patient outcomes.</p></div>\",\"PeriodicalId\":15151,\"journal\":{\"name\":\"Journal of Biochemical and Molecular Toxicology\",\"volume\":\"39 9\",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biochemical and Molecular Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbt.70503\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biochemical and Molecular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbt.70503","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
The Effect of Clozapine on Immune-Related Biomarkers in Schizophrenia Patients
Schizophrenia is a prevalent mental disorder that significantly impacts global health, with approximately 1% of the population affected and around 30% of cases classified as treatment-resistant schizophrenia (TRS). Clozapine is established as the gold standard for TRS management, yet its use is often complicated by potential adverse effects and the necessity for rigorous blood monitoring due to the risk of severe neutropenia. Recent studies have revealed that clozapine not only influences psychiatric symptoms but also alters immune system functioning and cytokine profiles in patients with schizophrenia. This interplay between clozapine treatment and immune-related biomarkers warrants deeper investigation to elucidate the underlying mechanisms of the disease and to refine therapeutic approaches. Identifying specific biomarkers could enhance clinical decision-making regarding the initiation of clozapine therapy, allowing for more tailored treatments and improved patient outcomes.
期刊介绍：
The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.
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