自闭症谱系障碍的脉络膜丛改变:PET-MRI研究。

IF 7.6 2区 医学 Q1 IMMUNOLOGY
Ylind Lila , Chieh-En Jane Tseng , Emma G. Johnston , Camila Canales , Christopher J. McDougle , Jacob M. Hooker , Nicole R. Zürcher
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引用次数: 0

摘要

脉络膜丛(CP)主要被称为脑脊液(CSF)的产生部位,是血-CSF屏障的部位之一,在炎症传播中起着独特的作用,是免疫反应的关键调节剂。最近的研究表明,免疫相关的神经和精神疾病中CP增大。为了研究自闭症谱系障碍(ASD)体内潜在的神经免疫和结构改变,我们评估了自闭症成人线粒体转位蛋白(TSPO)的CP定位表达和CP体积。65名参与者,包括36名自闭症参与者和29名非自闭症对照组(CON),使用TSPO放射性示踪剂[11C]PBR28完成了正电子发射断层扫描-磁共振成像(PET-MRI)扫描。使用受试者水平解剖扫描对CP进行分割。我们观察到ASD患者脑膜CP体积增大(组平均差异:677.8,95 % CI [331.0, 1025.0], p = 0.0002)。特别是,自闭症成人的CP体积为~ 30 %,比对照组的平均CP体积高出2个标准差以上。考虑性别的探索性分析显示,自闭症男性的脉络丛体积与更严重的ASD症状相关(估计贝塔系数:153.10,95 % CI [50.03, 256.30], p = 0.005),自闭症女性的CP中TSPO升高(平均组差0.12,95 % CI [0.03, 0.21], p = 0.01)。我们的研究结果揭示了ASD中人类CP的体积变化,为ASD中CP的参与提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Choroid plexus alterations in autism spectrum disorder: A PET-MRI study
The choroid plexus (CP), primarily known as the production site of cerebrospinal fluid (CSF), constitutes one of the sites of the blood-CSF barrier and plays a unique role in inflammation propagation, serving as a key regulator of immune responses. Recent work has shown CP enlargement in neurological and psychiatric disorders with immune involvement. To investigate potential neuroimmune and structural alterations in vivo in autism spectrum disorder (ASD), we assessed the CP-localized expression of mitochondrial translocator protein (TSPO) and CP volume in autistic adults. Sixty-five participants, which included 36 autistic participants and 29 non-autistic controls (CON), completed a simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI) scan with the TSPO radiotracer [11C]PBR28. The CP was segmented using subject-level anatomical scans. We observed CP volume enlargement in ASD (mean group difference: 677.8, 95 % CI [331.0, 1025.0], p = 0.0002). In particular, the CP volume of ∼30 % of autistic adults was more than 2 standard deviations above the average CP volume of CON. Exploratory analysis considering sex showed that CP volume was associated with more severe ASD symptoms in autistic males (estimated beta: 153.10, 95 % CI [50.03, 256.30], p = 0.005) and that TSPO in the CP was elevated in autistic females (mean group difference 0.12, 95 % CI [0.03, 0.21], p = 0.01). Our findings reveal volumetric alterations of the human CP in ASD, providing novel insights into the involvement of the CP in ASD.
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来源期刊
CiteScore
29.60
自引率
2.00%
发文量
290
审稿时长
28 days
期刊介绍: Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.
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