Tatchaporn Ongphichetmetha, Mengke Du, Nisa Vorasoot, Sean J. Pittock, Jeffrey A. Cohen, Amy Kunchok
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Frequency of Seroconversion in Aquaporin-4 Antibody Testing: Insights From Real-World Data
Clinicians often repeat aquaporin-4-immunoglobulin G (AQP4-IgG) testing in case of possible seroconversion. Compared with older, less sensitive immunofluorescence assays (IFA), cell-based assays (CBA) offer higher sensitivity. This study assessed the frequency of seroconversion in a retrospective Cleveland Clinic cohort (2006–2024) of 451 patients with an initial negative AQP4-IgG result who underwent serial testing. Seroconversion occurred in 4.3% (7/170) of patients initially tested by tissue IFA, but in none (0/263) of those tested by CBA. The lack of AQP4-IgG seroconversion after a negative CBA, with only rare cases after a negative IFA, suggests that repeat AQP4-IgG testing is low yield unless prior testing used older methods such as IFA.
期刊介绍：
Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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