水通道蛋白-4抗体检测的血清转换频率：来自真实世界数据的见解。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2025-09-17 DOI:10.1002/acn3.70185

Tatchaporn Ongphichetmetha, Mengke Du, Nisa Vorasoot, Sean J Pittock, Jeffrey A Cohen, Amy Kunchok

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引用次数: 0

摘要

临床医生经常重复水通道蛋白-4免疫球蛋白G （AQP4-IgG）检测，以防可能的血清转化。与较老的灵敏度较低的免疫荧光测定法（IFA）相比，基于细胞的测定法（CBA）具有更高的灵敏度。本研究评估了克利夫兰诊所回顾性队列（2006-2024）中451例初始AQP4-IgG结果为阴性并接受系列检测的患者的血清转化频率。在最初接受组织IFA检测的患者中，有4.3%（7/170）发生血清转化，但在接受CBA检测的患者中没有发生血清转化（0/263）。在CBA阴性后缺乏AQP4-IgG血清转化，只有极少数病例在IFA阴性后，提示重复AQP4-IgG检测是低收率的，除非先前检测使用较旧的方法，如IFA。

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Frequency of Seroconversion in Aquaporin-4 Antibody Testing: Insights From Real-World Data.

Clinicians often repeat aquaporin-4-immunoglobulin G (AQP4-IgG) testing in case of possible seroconversion. Compared with older, less sensitive immunofluorescence assays (IFA), cell-based assays (CBA) offer higher sensitivity. This study assessed the frequency of seroconversion in a retrospective Cleveland Clinic cohort (2006-2024) of 451 patients with an initial negative AQP4-IgG result who underwent serial testing. Seroconversion occurred in 4.3% (7/170) of patients initially tested by tissue IFA, but in none (0/263) of those tested by CBA. The lack of AQP4-IgG seroconversion after a negative CBA, with only rare cases after a negative IFA, suggests that repeat AQP4-IgG testing is low yield unless prior testing used older methods such as IFA.

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.