Evaluating the Impact of Adding Herbal Medicine into Standard Treatment for Patients with Primary Hypertension in Comparison to a Placebo: A Triple-Blinded Randomized Controlled Trial

Purpuse

This research was conducted to assess the impact of Gaznab syrup (aqueous extract of Urtica dioica and Ziziphus jujube) on systolic and diastolic blood pressure levels in patients diagnosed with hypertension (stage I).

Methods

We executed a triple-blinded, randomized controlled trial involving 36 participants (ages 30–65 years) who were administered either Gaznab syrup (intervention group, 5 cc, n = 18) or a placebo (control group, 5 cc, n = 18) twice daily as supplementary treatment over an 8-week duration. Systolic and diastolic blood pressures were measured initially at baseline and subsequently at weeks 4 and 8. Furthermore, laboratory analyses and side effects were conducted.

Results

The mean systolic blood pressure (MSBP) at baseline in the Intervention and Control groups was 146. 63 ± 4. 56 mmHg and 147. 00 ± 4. 00 mmHg, respectively (p = 0.814). By the conclusion of the study, MSBP and standard deviation in the intervention and control groups were recorded at 134. 94 ± 8. 17 mmHg and 147. 63 ± 5. 04 mmHg, respectively (p = 0.001). The mean diastolic blood pressure (MDBP) at baseline for the intervention and control groups was 91. 97 ± 2. 45 mmHg and 92. 77 ± 2. 06 mmHg, respectively (p = 0.294); at the end of the study, MDBP in the Intervention and Control groups was found to be 85. 25 ± 4. 04 mmHg and 92. 75 ± 2. 34 mmHg, respectively (p < 0.000).

Conclusion

According to the findings, Gaznab syrup can markedly lower both systolic and diastolic blood pressure levels in individuals suffering from essential hypertension.