隐含不良反应入院:一项队列研究引入了一种新的行政数据方法来识别与药物相关的住院。

IF 3.8 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Miriam Schechner, Marietta Rottenkolber, Clara Weglage, Vita Brišnik, Annette Haerdtlein, Bruce Guthrie, Ulrich Jaehde, Eva Grill, Tobias Dreischulte
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引用次数: 0

摘要

背景:药物不良反应(adr)是计划外住院的一个关键因素,特别是在使用多种药物的患者中。传统的检测方法,如专家评审或诊断编码,在可扩展性和灵敏度方面受到限制。目的:本研究介绍并评估了一种新的可扩展方法,即隐含不良反应入院,该方法利用行政数据将药物暴露与不良事件联系起来,以提高对合理的药物相关住院的检测。方法:回顾性队列研究使用来自苏格兰两个卫生局的123,662名年龄≥40岁的多药患者的相关健康数据。隐含不良反应入院被定义为在过去90天内,因15种不良事件中的一种可能与药物暴露相关(基于结构化共识过程)而急诊住院。发生率比较了三种现有的方法:不良事件入院(与药物暴露无关),明确的不良反应入院(明确编码为不良反应)和可预防的不良反应入院(既往用药错误)。多变量逻辑回归用于确定隐含不良反应入院的预测因素。结果:在1年的时间里,2.6%的患者发生了默示的不良反应入院,5.7%的患者发生了不良事件入院,0.4%的患者发生了明确的不良反应入院。对于消化道出血,隐含的adr入院发生率比可预防的adr入院发生率高20倍。潜在不良反应入院的关键预测因素包括先前与低钾血症相关的住院治疗和使用可能不适当的药物。结论:相对于广泛的不良事件定义,隐含的ADR入院方法具有更高的特异性,同时比仅依赖明确的ADR代码或预先指定的药物错误的方法提高了敏感性。它为药物警戒提供了一种可扩展的自动化工具,尽管在常规使用药物安全监测之前需要进一步验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Implied ADR-Admissions: A Cohort Study Introducing a Novel Administrative Data Approach for Identifying Drug-Related Hospitalisations.

Background: Adverse drug reactions (ADRs) are a key contributor to unplanned hospitalisations, particularly in patients with polypharmacy. Traditional detection methods, such as expert reviews or diagnostic coding, are limited in scalability and sensitivity.

Objective: This study introduces and evaluates a novel scalable method, implied ADR-admissions, that links drug exposures to adverse events using administrative data to improve the detection of plausible drug-related hospitalisations.

Methods: A retrospective cohort study was conducted using linked health data from 123,662 individuals aged ≥ 40 years with polypharmacy in two Scottish health boards. Implied ADR-admissions were defined as emergency hospitalisations with one of 15 adverse events plausibly linked to drug exposure (based on a structured consensus process) within the prior 90 days. Incidence was compared with three existing approaches: adverse event-admissions (regardless of drug exposure), explicit ADR-admissions (explicitly coded as ADRs) and preventable ADR-admissions (with prior medication error). Multivariate logistic regression was used to identify predictors of implied ADR-admissions.

Results: Over 1 year, 2.6% experienced an implied ADR-admission, compared with 5.7% with adverse event-admissions, and 0.4% with explicit ADR-admissions. For gastrointestinal bleeding, the implied ADR-admission incidence was 20 times higher than the preventable ADR-admission incidence. Key predictors for implied ADR-admissions included prior hypokalaemia-related hospitalisation and use of potentially inappropriate medications.

Conclusions: The implied ADR-admission approach has improved specificity relative to broad adverse event definitions while enhancing sensitivity beyond methods that rely solely on explicit ADR codes or pre-specified medication errors. It offers a scalable automated tool for pharmacovigilance, though further validation is needed prior to routine use in medication safety monitoring.

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来源期刊
Drug Safety
Drug Safety 医学-毒理学
CiteScore
7.60
自引率
7.10%
发文量
112
审稿时长
6-12 weeks
期刊介绍: Drug Safety is the official journal of the International Society of Pharmacovigilance. The journal includes: Overviews of contentious or emerging issues. Comprehensive narrative reviews that provide an authoritative source of information on epidemiology, clinical features, prevention and management of adverse effects of individual drugs and drug classes. In-depth benefit-risk assessment of adverse effect and efficacy data for a drug in a defined therapeutic area. Systematic reviews (with or without meta-analyses) that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. Original research articles reporting the results of well-designed studies in disciplines such as pharmacoepidemiology, pharmacovigilance, pharmacology and toxicology, and pharmacogenomics. Editorials and commentaries on topical issues. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Drug Safety Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.
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