Ellie McCluey, Ahmad A Toubasi, Jiacheng Wang, Habeeb F Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato
{"title":"慢性活动性病变与白质疾病之间的关系：一项7特斯拉成像研究","authors":"Ellie McCluey, Ahmad A Toubasi, Jiacheng Wang, Habeeb F Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato","doi":"10.1002/acn3.70101","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored.</p><p><strong>Objectives: </strong>To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.</p><p><strong>Methods: </strong>PRLs were identified on susceptibility weighted imaging (SWI) of 68 newly diagnosed patients. Each PRL was paired with an anatomically matched contralateral non-PRL (nPRL) from the same participant. Quantitative magnetization transfer imaging derived macromolecular-to-free pool-size ratio (PSR) and relaxation rate of the free water pool (R<sub>1f</sub>) values were extracted and compared between PRLs and nPRLs, NAWM surrounding PRLs and nPRLs, and whole brain WM lesions and NAWM of PRL+ and PRL- people with MS (pwMS).</p><p><strong>Results: </strong>PSR and R<sub>1f</sub> (p ≤ 0.028) values were lower in PRLs compared to nPRLs, but there were no differences in PSR and R<sub>1f</sub> (p ≥ 0.824) values between peri-PRLs and peri-nPRLs NAWM ROIs. PRL+ pwMS had similar PSR and R<sub>1f</sub> (p ≥ 0.267) of the whole brain NAWM, similar WM lesions PSR (p = 0.764) but lower R<sub>1f</sub> (p = 0.030) values.</p><p><strong>Conclusions: </strong>In the early stages of MS, there is no association between PRLs and surrounding NAWM degree of injury.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study.\",\"authors\":\"Ellie McCluey, Ahmad A Toubasi, Jiacheng Wang, Habeeb F Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato\",\"doi\":\"10.1002/acn3.70101\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored.</p><p><strong>Objectives: </strong>To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.</p><p><strong>Methods: </strong>PRLs were identified on susceptibility weighted imaging (SWI) of 68 newly diagnosed patients. Each PRL was paired with an anatomically matched contralateral non-PRL (nPRL) from the same participant. Quantitative magnetization transfer imaging derived macromolecular-to-free pool-size ratio (PSR) and relaxation rate of the free water pool (R<sub>1f</sub>) values were extracted and compared between PRLs and nPRLs, NAWM surrounding PRLs and nPRLs, and whole brain WM lesions and NAWM of PRL+ and PRL- people with MS (pwMS).</p><p><strong>Results: </strong>PSR and R<sub>1f</sub> (p ≤ 0.028) values were lower in PRLs compared to nPRLs, but there were no differences in PSR and R<sub>1f</sub> (p ≥ 0.824) values between peri-PRLs and peri-nPRLs NAWM ROIs. PRL+ pwMS had similar PSR and R<sub>1f</sub> (p ≥ 0.267) of the whole brain NAWM, similar WM lesions PSR (p = 0.764) but lower R<sub>1f</sub> (p = 0.030) values.</p><p><strong>Conclusions: </strong>In the early stages of MS, there is no association between PRLs and surrounding NAWM degree of injury.</p>\",\"PeriodicalId\":126,\"journal\":{\"name\":\"Annals of Clinical and Translational Neurology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Clinical and Translational Neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/acn3.70101\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Clinical and Translational Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/acn3.70101","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study.
Background: The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored.
Objectives: To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Methods: PRLs were identified on susceptibility weighted imaging (SWI) of 68 newly diagnosed patients. Each PRL was paired with an anatomically matched contralateral non-PRL (nPRL) from the same participant. Quantitative magnetization transfer imaging derived macromolecular-to-free pool-size ratio (PSR) and relaxation rate of the free water pool (R1f) values were extracted and compared between PRLs and nPRLs, NAWM surrounding PRLs and nPRLs, and whole brain WM lesions and NAWM of PRL+ and PRL- people with MS (pwMS).
Results: PSR and R1f (p ≤ 0.028) values were lower in PRLs compared to nPRLs, but there were no differences in PSR and R1f (p ≥ 0.824) values between peri-PRLs and peri-nPRLs NAWM ROIs. PRL+ pwMS had similar PSR and R1f (p ≥ 0.267) of the whole brain NAWM, similar WM lesions PSR (p = 0.764) but lower R1f (p = 0.030) values.
Conclusions: In the early stages of MS, there is no association between PRLs and surrounding NAWM degree of injury.
期刊介绍：
Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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