从古细菌中提取抗生素

IF 41.7 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Iris Marchal
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引用次数: 0

摘要

大多数抗生素的发现工作都集中在细菌和真菌上,而对古细菌领域的探索不足。古细菌在进化上与细菌和真核生物不同,导致独特的代谢途径和防御机制,可能导致结构和功能上独特的加密肽-在较大的蛋白质中具有抗菌活性的短序列。Torres等人在《自然微生物学》杂志上发表文章称,他们现在利用人工智能来探索古菌群的序列空间,寻找新的抗菌化合物。作者使用深度学习模型APEX的更新版本来挖掘233个古细菌蛋白质组,确定了12623个具有潜在抗菌活性的肽序列,他们称之为古菌蛋白酶。排序最多样化的古菌蛋白酶来源于具有不同功能和分布的蛋白质。它们的氨基酸谱与数据库中已知的抗菌肽不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mining archaea for antibiotics
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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