{"title":"连杆不平衡的一种均匀测量。","authors":"Mark M. Tanaka","doi":"10.1016/j.tpb.2025.09.002","DOIUrl":null,"url":null,"abstract":"<div><div>Linkage disequilibrium (LD), the association of alleles at two loci, is defined in multiple ways. Because LD measures depend on allele frequencies, it is difficult to compare LD values between populations or loci with different allele frequencies. Here, I consider a geometric interpretation of a commonly used LD measure <span><math><msup><mrow><mi>r</mi></mrow><mrow><mn>2</mn></mrow></msup></math></span> which suggests a modification that is frequency-independent in the sense that equal evolutionary forces lead to the same effect at different frequencies. This new measure is a very simple expression that is known elsewhere as the Hamann coefficient and the G index of agreement; it is a linear transformation of the simple matching coefficient. I explore properties of this quantity in comparison with <span><math><mi>D</mi></math></span> and <span><math><msup><mrow><mi>r</mi></mrow><mrow><mn>2</mn></mrow></msup></math></span>, and discuss its interpretation, advantages and disadvantages.</div></div>","PeriodicalId":49437,"journal":{"name":"Theoretical Population Biology","volume":"166 ","pages":"Pages 36-43"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An equal-tempered measure of linkage disequilibrium\",\"authors\":\"Mark M. Tanaka\",\"doi\":\"10.1016/j.tpb.2025.09.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Linkage disequilibrium (LD), the association of alleles at two loci, is defined in multiple ways. Because LD measures depend on allele frequencies, it is difficult to compare LD values between populations or loci with different allele frequencies. Here, I consider a geometric interpretation of a commonly used LD measure <span><math><msup><mrow><mi>r</mi></mrow><mrow><mn>2</mn></mrow></msup></math></span> which suggests a modification that is frequency-independent in the sense that equal evolutionary forces lead to the same effect at different frequencies. This new measure is a very simple expression that is known elsewhere as the Hamann coefficient and the G index of agreement; it is a linear transformation of the simple matching coefficient. I explore properties of this quantity in comparison with <span><math><mi>D</mi></math></span> and <span><math><msup><mrow><mi>r</mi></mrow><mrow><mn>2</mn></mrow></msup></math></span>, and discuss its interpretation, advantages and disadvantages.</div></div>\",\"PeriodicalId\":49437,\"journal\":{\"name\":\"Theoretical Population Biology\",\"volume\":\"166 \",\"pages\":\"Pages 36-43\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Theoretical Population Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040580925000607\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theoretical Population Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040580925000607","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ECOLOGY","Score":null,"Total":0}
An equal-tempered measure of linkage disequilibrium
Linkage disequilibrium (LD), the association of alleles at two loci, is defined in multiple ways. Because LD measures depend on allele frequencies, it is difficult to compare LD values between populations or loci with different allele frequencies. Here, I consider a geometric interpretation of a commonly used LD measure which suggests a modification that is frequency-independent in the sense that equal evolutionary forces lead to the same effect at different frequencies. This new measure is a very simple expression that is known elsewhere as the Hamann coefficient and the G index of agreement; it is a linear transformation of the simple matching coefficient. I explore properties of this quantity in comparison with and , and discuss its interpretation, advantages and disadvantages.
期刊介绍:
An interdisciplinary journal, Theoretical Population Biology presents articles on theoretical aspects of the biology of populations, particularly in the areas of demography, ecology, epidemiology, evolution, and genetics. Emphasis is on the development of mathematical theory and models that enhance the understanding of biological phenomena.
Articles highlight the motivation and significance of the work for advancing progress in biology, relying on a substantial mathematical effort to obtain biological insight. The journal also presents empirical results and computational and statistical methods directly impinging on theoretical problems in population biology.