Hao-Jie Wang, Jian-Ying Cui, Wen-Jie Hou, Xu-Lei Hao, Wen-Qi Zheng, Zhi-De Hu, Xi-Shan Cao, Li Yan
{"title":"SHOX-2甲基化对恶性胸腔积液的诊断准确性：一项系统回顾和荟萃分析。","authors":"Hao-Jie Wang, Jian-Ying Cui, Wen-Jie Hou, Xu-Lei Hao, Wen-Qi Zheng, Zhi-De Hu, Xi-Shan Cao, Li Yan","doi":"10.21037/tcr-2025-686","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Some studies have assessed the diagnostic value of SHOX-2 methylation for malignant pleural effusion (MPE), but their findings were inconsistent. This study aimed to conduct a systematic review and meta-analysis to evaluate the diagnostic accuracy of SHOX-2 methylation for MPE.</p><p><strong>Methods: </strong>We searched the PubMed and Web of Science databases to identify studies involving SHOX-2 methylation in diagnosing MPE. The last search date was in December 2024. We evaluated the quality of the included studies using the revised Quality Assessment of Diagnostic Accuracy Studies tool-2 (QUADAS-2). A bivariate model was used to pool the sensitivity, specificity, and their 95% confidence intervals (CIs) of SHOX-2 methylation. The overall diagnostic accuracy of SHOX-2 methylation was assessed by a summary receiver operating characteristic (sROC) curve. The publication bias was analyzed using Deek's test.</p><p><strong>Results: </strong>Six studies with 613 MPE patients and 723 benign pleural effusion (BPE) patients were included. The pooled sensitivity (95% CI) and specificity (95% CI) of SHOX-2 methylation were 0.64 (0.36-0.85) and 0.96 (0.92-0.98), respectively. The area under the sROC curve was 0.96 (95% CI: 0.94-0.97). There was no publication bias across the eligible studies.</p><p><strong>Conclusions: </strong>SHOX-2 methylation has a moderate diagnostic value for MPE.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 8","pages":"4955-4964"},"PeriodicalIF":1.7000,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432786/pdf/","citationCount":"0","resultStr":"{\"title\":\"Diagnostic accuracy of SHOX-2 methylation for malignant pleural effusion: a systematic review and meta-analysis.\",\"authors\":\"Hao-Jie Wang, Jian-Ying Cui, Wen-Jie Hou, Xu-Lei Hao, Wen-Qi Zheng, Zhi-De Hu, Xi-Shan Cao, Li Yan\",\"doi\":\"10.21037/tcr-2025-686\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Some studies have assessed the diagnostic value of SHOX-2 methylation for malignant pleural effusion (MPE), but their findings were inconsistent. This study aimed to conduct a systematic review and meta-analysis to evaluate the diagnostic accuracy of SHOX-2 methylation for MPE.</p><p><strong>Methods: </strong>We searched the PubMed and Web of Science databases to identify studies involving SHOX-2 methylation in diagnosing MPE. The last search date was in December 2024. We evaluated the quality of the included studies using the revised Quality Assessment of Diagnostic Accuracy Studies tool-2 (QUADAS-2). A bivariate model was used to pool the sensitivity, specificity, and their 95% confidence intervals (CIs) of SHOX-2 methylation. The overall diagnostic accuracy of SHOX-2 methylation was assessed by a summary receiver operating characteristic (sROC) curve. The publication bias was analyzed using Deek's test.</p><p><strong>Results: </strong>Six studies with 613 MPE patients and 723 benign pleural effusion (BPE) patients were included. The pooled sensitivity (95% CI) and specificity (95% CI) of SHOX-2 methylation were 0.64 (0.36-0.85) and 0.96 (0.92-0.98), respectively. The area under the sROC curve was 0.96 (95% CI: 0.94-0.97). There was no publication bias across the eligible studies.</p><p><strong>Conclusions: </strong>SHOX-2 methylation has a moderate diagnostic value for MPE.</p>\",\"PeriodicalId\":23216,\"journal\":{\"name\":\"Translational cancer research\",\"volume\":\"14 8\",\"pages\":\"4955-4964\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432786/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational cancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21037/tcr-2025-686\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational cancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/tcr-2025-686","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/19 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Diagnostic accuracy of SHOX-2 methylation for malignant pleural effusion: a systematic review and meta-analysis.
Background: Some studies have assessed the diagnostic value of SHOX-2 methylation for malignant pleural effusion (MPE), but their findings were inconsistent. This study aimed to conduct a systematic review and meta-analysis to evaluate the diagnostic accuracy of SHOX-2 methylation for MPE.
Methods: We searched the PubMed and Web of Science databases to identify studies involving SHOX-2 methylation in diagnosing MPE. The last search date was in December 2024. We evaluated the quality of the included studies using the revised Quality Assessment of Diagnostic Accuracy Studies tool-2 (QUADAS-2). A bivariate model was used to pool the sensitivity, specificity, and their 95% confidence intervals (CIs) of SHOX-2 methylation. The overall diagnostic accuracy of SHOX-2 methylation was assessed by a summary receiver operating characteristic (sROC) curve. The publication bias was analyzed using Deek's test.
Results: Six studies with 613 MPE patients and 723 benign pleural effusion (BPE) patients were included. The pooled sensitivity (95% CI) and specificity (95% CI) of SHOX-2 methylation were 0.64 (0.36-0.85) and 0.96 (0.92-0.98), respectively. The area under the sROC curve was 0.96 (95% CI: 0.94-0.97). There was no publication bias across the eligible studies.
Conclusions: SHOX-2 methylation has a moderate diagnostic value for MPE.
期刊介绍：
Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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