珍芪补虚口服液通过下调TNF-介导的炎症通路改善小鼠炎症和衰老相关功能障碍。

IF 5.4 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of ethnopharmacology Pub Date : 2025-09-12 DOI:10.1016/j.jep.2025.120611

Xinqing Jiang , Weidong Ye , Zhengkai Wang , Keying Zhu , Jun Ping , Liujun Xu , Beier Jiang , Shengmei Zhu , Maoxiang Qian , Lifeng Xu , Feng Zhang , Sijia Chen

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引用次数: 0

摘要

民族药理学相关性：衰老与一种被称为“炎症”的持续、低级别炎症状态有关，这是由衰老细胞的积累及其衰老相关分泌表型（SASP）驱动的。珍芪补虚口服液（ZQBX）是一种广泛使用的中药配方，已知可治疗人体虚弱并具有潜在的抗衰老作用。研究目的：探讨ZQBX的老年保护作用及其机制。方法：采用自然衰老小鼠模型，评价中药复方ZQBX干预对衰老的影响。采用组织染色、血清ELISA、物理功能分析、网络药理分析、分子对接分析等方法描述ZQBX的表型和作用机制。结果：ZQBX治疗可以防止衰老小鼠肝功能下降和肝脂肪变性，减轻慢性炎症，改善胰岛素敏感性和葡萄糖代谢。机械上，ZQBX通过抑制TNF-α信号通路，降低衰老肝细胞中的SASP，延缓肝脏衰老。结论：ZQBX在调节衰老相关表型中的药理意义暗示其在调节衰老细胞活性方面的潜在益处，可能对未来的老年医学有贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Zhenqi Buxu oral liquid ameliorates inflammaging and aging associated dysfunction via downregulation of TNF-ɑ-mediated inflammatory pathways in mice

查看原文本刊更多论文

Zhenqi Buxu oral liquid ameliorates inflammaging and aging associated dysfunction via downregulation of TNF-ɑ-mediated inflammatory pathways in mice

Ethnopharmacological relevance

Aging is associated with a persistent, low-grade inflammatory state termed “inflammaging”, driven by the accumulation of senescent cells and their senescence-associated secretory phenotype (SASP). Zhenqi Buxu Oral Liquid (ZQBX) is a widely used traditional Chinese medicine formula known to treat human weakness and have potential anti-aging effects.

Aim of study

To explore the geroprotective effects of ZQBX and its underlying mechanisms.

Methods

We used a natural aging mouse model to evaluate the effects of ZQBX intervention on aging. Tissue staining, serum ELISA assays, physical function analysis, network pharmacological analysis and molecular docking analysis were employed to describe the phenotypic and mechanistic effects of ZQBX.

Results

ZQBX treatment protected against age-related declines in liver function and hepatic steatosis, mitigated chronic inflammation, and improved insulin sensitivity and glucose metabolism in aged mice. Mechanically, ZQBX reduced SASP in senescent hepatic cells to delay liver aging through inhibiting the TNF-α signaling pathway.

Conclusion

The pharmacological significance of ZQBX in modulating senescence-associated phenotypes implies its potential benefits in regulating the activities of senescent cells, suggesting possible contributions to future geriatric medicine.

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来源期刊

Journal of ethnopharmacology 医学-全科医学与补充医学

CiteScore

10.30

自引率

5.60%

发文量

967

审稿时长

77 days

期刊介绍： The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.