再生到“年轻化”：来自成年扁平虫和小鼠的成年常驻干细胞的见解。

IF 7.1 1区医学 Q1 CELL BIOLOGY

Aging Cell Pub Date : 2025-09-14 DOI:10.1111/acel.70236

Kevin A Murach, Cory M Dungan, Toby L Chambers, Steve Horvath, Jayakrishnan Nandakumar, Vadim N Gladyshev, Scott D Pletcher, Xiaoting Dai, Longhua Guo

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引用次数: 0

摘要

成年常驻干细胞能够再生组织，在扁形虫和老年小鼠中表现出“返老还老”的迹象。这些发现提示了从蠕虫到哺乳动物的成体常驻干细胞潜在的保守调节机制。在大型哺乳动物的特定组织和干细胞类型中，再生能力更为有限。理解和利用扁形虫和小鼠体内常驻成体干细胞的再生特性，可能对改善老年人类各器官系统的干细胞功能和组织可塑性具有广泛的治疗意义。

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Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.

Adult resident stem cells are capable of regenerating tissues that manifest signs of "rejuvenation" in flatworms and mice of older ages. These findings suggest potentially conserved regulatory mechanisms of adult resident stem cells from worms to mammals. Regenerative capacities are more limited in specific tissues and stem cell types of larger mammals. Understanding and harnessing the rejuvenating properties of resident adult stem cells in flatworms and mice could have broad therapeutic implications for improving stem cell function and tissue plasticity across organ systems of humans in advanced age.

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来源期刊

Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology

自引率

2.60%

发文量

212

期刊介绍： Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.