A bottomless well: 1,2,4-Triazoles continue to inspire scientific researchers to develop more and more anticancer molecules

1,2,4-Triazoles represent an endless source of clinically bioactive molecules, captivating scientific researchers with their diverse biological activities. This review explores the recent approaches employed by chemists and biologists in the synthesis and biological activity assessment of more than two hundred 1,2,4-triazole anticancer candidates that have been reported throughout 2020–2025. The review also explores the different biological targets these compounds act upon, like A2B, STAT, VEGFR, EGFR, p97, aromatase, and ferroptosis. Mechanistic insights into how these derivatives exert their actions are discussed, highlighting their potential uses in medicine. Given that comprehensive overview in the field, this review tries to inspire and guide future research.