从理论到实践:腹膜假性黏液瘤研究综述及其对未来治疗的意义。

IF 3.6 2区 医学 Q1 PATHOLOGY
Han Gao, Hongli Wang, Xiufeng Li, Fulei Zhang, Yiru Ba, Jiatong Zhao, Chengwei He, Shuzi Xin, Xiaohui Liu, Guowei Liang
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引用次数: 0

摘要

腹膜假性粘液瘤(PMP)是一种罕见的疾病,其症状为粘液性腹水和大网膜饼,通常由阑尾穿孔的上皮肿瘤引起。由于其罕见性、非特异性的组织学特征和缓慢的进展,其发病机制和最佳治疗仍然是争论的主题。PMP仍然是一个具有挑战性和神秘的条件。越来越多的全球关注的方向是了解其发病机制和建立标准的治疗方法。PMP和粘蛋白有着千丝万缕的联系。本文强调粘蛋白在本病发病机制中的重要作用。本文还讨论了几种消除PMP中粘蛋白的潜在治疗策略。肿瘤的发展和转移涉及一系列步骤,包括肿瘤与宿主源性基质环境的相互作用,促进血管生成和炎症细胞的激活。炎症因子和趋化因子在PMP的进展和发展中起着至关重要的作用。微生物组和特定微生物可能直接影响PMP的肿瘤发生、进展和对某些治疗的反应。因此,本文综述了PMP中细菌、免疫系统和粘蛋白的相互作用,重点探讨了粘蛋白异常与肿瘤生长的相关机制。本文对PMP的临床特征、病理过程和治疗方案进行了综述,旨在指导未来的研究,以确定新的治疗靶点和肠道相关疾病的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From Theory to Practice: A Comprehensive Review of Pseudomyxoma Peritonei Research and Its Implications for Future Treatment.

Pseudomyxoma peritonei (PMP) is a rare disease characterized by symptoms such as mucinous ascites and omental cake, typically arising from a perforated epithelial tumor of the appendix. Because of its rarity, non-specific histologic characteristics, and slow progression, its pathogenesis and optimal treatment remain subjects of debate. PMP is still a challenging and enigmatic condition. Increasing global attention is being directed toward understanding its pathogenesis and establishing standard treatment approaches. PMP and mucin are inextricably linked. This article highlighted the important role of mucin in the disease's pathogenesis. It also discussed several potential therapeutic strategies for eliminating mucin in PMP. Tumor development and metastasis involve a series of steps that include the interaction between the tumor and the host-derived stromal environment, which promotes angiogenesis and activation of inflammatory cells. Inflammatory cytokines and chemokines play a crucial role in the progression and development of PMP. The microbiome and specific microorganisms may directly influence tumor development, progression, and responses to certain therapies in PMP. Thus, the article summarized the interactions among bacteria, the immune system, and mucin in PMP, focusing on the mechanisms that related to abnormal mucin and tumor growth. This review critically examined the existing literature on the clinical features, pathologic processes, and treatment options in PMP, aiming to guide future research toward identifying novel therapeutic targets and gut-related disease biomarkers.

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来源期刊
CiteScore
11.40
自引率
0.00%
发文量
178
审稿时长
30 days
期刊介绍: The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.
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