{"title":"外周组织层粘连蛋白受体——敲除小鼠分析揭示的功能。","authors":"Wanling Xuan, Yao Yao","doi":"10.1016/j.ajpath.2025.08.007","DOIUrl":null,"url":null,"abstract":"<p><p>Laminin, by interacting with its receptors (mainly integrins and dystroglycan), exerts a variety of important functions in multiple organs. Loss-of-function studies have described the essential roles of laminin receptors in both physiological and pathologic conditions. This review summarizes the pathology and loss-of-function phenotypes of laminin receptors, including integrin-α3, integrin-α6, integrin-α7, integrin-β1, integrin-β4, and dystroglycan, focusing on the skin, kidney, skeletal muscle, peripheral nervous system, mammary gland, lung, and heart. To explore the functional redundancy/compensation among different laminin receptors, the phenotypes of compound knockout mice are compared with that of single mutants. Next, key signaling pathways downstream of each laminin receptor are summarized and compared. In addition, key questions in the field and future directions are also discussed. The aim of this review was to provide a synthetic review on loss-of-function studies of laminin receptors and foster the formation and testing of new hypotheses in the field.</p>","PeriodicalId":7623,"journal":{"name":"American Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Laminin Receptors in Peripheral Tissues: Functions Revealed by Analysis of Knockout Mice.\",\"authors\":\"Wanling Xuan, Yao Yao\",\"doi\":\"10.1016/j.ajpath.2025.08.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Laminin, by interacting with its receptors (mainly integrins and dystroglycan), exerts a variety of important functions in multiple organs. Loss-of-function studies have described the essential roles of laminin receptors in both physiological and pathologic conditions. This review summarizes the pathology and loss-of-function phenotypes of laminin receptors, including integrin-α3, integrin-α6, integrin-α7, integrin-β1, integrin-β4, and dystroglycan, focusing on the skin, kidney, skeletal muscle, peripheral nervous system, mammary gland, lung, and heart. To explore the functional redundancy/compensation among different laminin receptors, the phenotypes of compound knockout mice are compared with that of single mutants. Next, key signaling pathways downstream of each laminin receptor are summarized and compared. In addition, key questions in the field and future directions are also discussed. The aim of this review was to provide a synthetic review on loss-of-function studies of laminin receptors and foster the formation and testing of new hypotheses in the field.</p>\",\"PeriodicalId\":7623,\"journal\":{\"name\":\"American Journal of Pathology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajpath.2025.08.007\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajpath.2025.08.007","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
Laminin Receptors in Peripheral Tissues: Functions Revealed by Analysis of Knockout Mice.
Laminin, by interacting with its receptors (mainly integrins and dystroglycan), exerts a variety of important functions in multiple organs. Loss-of-function studies have described the essential roles of laminin receptors in both physiological and pathologic conditions. This review summarizes the pathology and loss-of-function phenotypes of laminin receptors, including integrin-α3, integrin-α6, integrin-α7, integrin-β1, integrin-β4, and dystroglycan, focusing on the skin, kidney, skeletal muscle, peripheral nervous system, mammary gland, lung, and heart. To explore the functional redundancy/compensation among different laminin receptors, the phenotypes of compound knockout mice are compared with that of single mutants. Next, key signaling pathways downstream of each laminin receptor are summarized and compared. In addition, key questions in the field and future directions are also discussed. The aim of this review was to provide a synthetic review on loss-of-function studies of laminin receptors and foster the formation and testing of new hypotheses in the field.
期刊介绍：
The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.
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