细胞外囊泡来源的miRNA在动脉粥样硬化负担中的作用。

IF 3.6 2区 医学 Q1 PATHOLOGY
Alessandra Stefania Rizzuto, Isabella Fichtner, Stefano Carugo, Annalisa Radeghieri, Chiara Macchi, Massimiliano Ruscica
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引用次数: 0

摘要

在动脉粥样硬化相关后遗症的背景下,细胞外囊泡(EVs)的作用继续引起人们的兴趣。它们在细胞间运输分子货物的能力突出了它们在细胞间通讯中的作用,因此它们在生理和病理过程的基础上参与介导分子事件。电动汽车将mirna封装在其腔内,保护它们不受循环核糖核酸酶的影响,否则核糖核酸酶会催化它们的降解。然而,关于ev中含有的microRNA (miR)在分子水平上调节生物活性的意义,一直存在争议。因此,本综述的目的是讨论ev衍生的miR的作用,重点讨论它们在动脉粥样硬化形成的分子机制中的意义。内皮来源的EVs可以通过传递靶向炎症通路成分的miR-10a来调节单核细胞活化。尾静脉给药来源于富集miR-34c-5p的内皮细胞的ev可显著降低动脉粥样硬化的进展。在稳定性冠状动脉疾病患者中,循环ev中miR-126和miR-199a水平升高与主要不良心血管事件发生率降低显著相关。这些由所有细胞释放到大多数生物液体中的纳米颗粒有望作为液体活检工具,因为它们的循环模式和货物可以反映心血管疾病的发病和严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Extracellular Vesicle-Derived miRNA in the Atherosclerotic Burden.

In the context of atheroma-related sequelae, the role of extracellular vesicles (EVs) continues to spike interest. Their ability to traffic molecular cargo between cells highlights their role in intercellular communication, and consequently their involvement in mediating molecular events at the basis of physiological and pathologic processes. EVs encapsulate miRNAs within their lumen, shielding them from circulating ribonucleases, which would otherwise catalyze their degradation. However, there is an ongoing debate regarding the implication of miRNA contained within EVs in modulating biological activities on a molecular level. Therefore, the aim of the present review is to discuss the role of EV-derived miRNA, focusing on their implication in molecular mechanisms underlying atheroma formation. EVs of endothelial origin can regulate monocyte activation by transferring miR-10a that targets components of the inflammatory pathway. Tail vein administration of EVs derived from endothelial cells enriched in miR-34c-5p markedly reduces atherosclerosis progression. In patients with stable coronary artery disease, elevated levels of miR-126 and miR-199a in circulating EVs are significantly associated with a reduced incidence of major adverse cardiovascular event rate. These nanoparticles, released by all cells into most biological fluids, hold promise as a liquid biopsy tool as their circulating patterns and cargo can reflect the onset and severity of cardiovascular diseases.

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来源期刊
CiteScore
11.40
自引率
0.00%
发文量
178
审稿时长
30 days
期刊介绍: The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.
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