Xiaobao Ma, Jiali Shen, Wei Wang, Lu Wang, Yulian Jin, Maoli Duan, Qing Zhang, Jun Yang, Jianyong Chen
{"title":"老年人前庭相关头晕持续时间与认知缺陷","authors":"Xiaobao Ma, Jiali Shen, Wei Wang, Lu Wang, Yulian Jin, Maoli Duan, Qing Zhang, Jun Yang, Jianyong Chen","doi":"10.1002/trc2.70153","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> OBJECTIVE</h3>\n \n <p>The objective of this study is to investigate the relationship between symptom duration of vestibular-related dizziness/vertigo and cognitive function in elderly patients, and to establish clinical guidance for assessing and intervening in vestibular-related cognitive impairments.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>This study included 100 elderly patients with vestibular dysfunction presenting dizziness, vertigo, or balance disorders, categorized into short-duration (<i>n</i> = 64) and long-duration (<i>n</i> = 36) groups based on symptom duration. A control group of 21 healthy elderly individuals was included. Cognitive assessments comprised P300 event-related potentials (latency/amplitude) and Montreal Cognitive Assessment (MoCA) with domain-specific analysis.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Significant between-group differences in P300 latency were observed (control vs short-duration vs long-duration: <i>p</i> < 0.001), whereas amplitude showed no difference (<i>p</i> = 0.817). MoCA total scores differed significantly across groups (<i>p</i> = 0.001), although abnormality rates were comparable (<i>p</i> = 0.093). Domain analysis revealed significant differences in visuospatial (<i>p</i> < 0.001) and abstract abilities (<i>p</i> = 0.005). Symptom duration correlated with: MoCA total (<i>R</i><sup>2</sup> = 0.113), visuospatial ability (<i>R</i><sup>2</sup> = 0.181), attention (<i>R</i><sup>2</sup> = 0.068), and orientation (<i>R</i><sup>2</sup> = 0.157). P300 latency correlated with: MoCA total (<i>R</i><sup>2</sup> = 0.141), visuospatial ability (<i>R</i><sup>2</sup> = 0.090), delayed recall (<i>R</i><sup>2</sup> = 0.112), and orientation (<i>R</i><sup>2</sup> = 0.082).</p>\n </section>\n \n <section>\n \n <h3> CONCLUSION</h3>\n \n <p>Prolonged vestibular-related dizziness/vertigo in elderly patients is associated with cognitive deficits, particularly in visuospatial and executive functions. P300 latency demonstrates greater sensitivity than both P300 amplitude and MoCA screening, suggesting that combined electrophysiological and neuropsychological assessment enhances early detection of vestibular-related cognitive impairment.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Long-duration vestibular-related dizziness or balance disorders are associated with a higher risk of cognitive impairment in elderly patients.</li>\n \n <li>Among early assessment tools, P300 latency proves more sensitive than both P300 amplitude and the Montreal Cognitive Assessment (MoCA) questionnaire.</li>\n \n <li>A combined evaluation using P300 latency and MoCA provides a more effective measure of how dizziness affects cognitive function in this population.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":53225,"journal":{"name":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","volume":"11 3","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70153","citationCount":"0","resultStr":"{\"title\":\"Vestibular-related dizziness duration and cognitive deficits in older adults\",\"authors\":\"Xiaobao Ma, Jiali Shen, Wei Wang, Lu Wang, Yulian Jin, Maoli Duan, Qing Zhang, Jun Yang, Jianyong Chen\",\"doi\":\"10.1002/trc2.70153\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> OBJECTIVE</h3>\\n \\n <p>The objective of this study is to investigate the relationship between symptom duration of vestibular-related dizziness/vertigo and cognitive function in elderly patients, and to establish clinical guidance for assessing and intervening in vestibular-related cognitive impairments.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>This study included 100 elderly patients with vestibular dysfunction presenting dizziness, vertigo, or balance disorders, categorized into short-duration (<i>n</i> = 64) and long-duration (<i>n</i> = 36) groups based on symptom duration. A control group of 21 healthy elderly individuals was included. Cognitive assessments comprised P300 event-related potentials (latency/amplitude) and Montreal Cognitive Assessment (MoCA) with domain-specific analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Significant between-group differences in P300 latency were observed (control vs short-duration vs long-duration: <i>p</i> < 0.001), whereas amplitude showed no difference (<i>p</i> = 0.817). MoCA total scores differed significantly across groups (<i>p</i> = 0.001), although abnormality rates were comparable (<i>p</i> = 0.093). Domain analysis revealed significant differences in visuospatial (<i>p</i> < 0.001) and abstract abilities (<i>p</i> = 0.005). Symptom duration correlated with: MoCA total (<i>R</i><sup>2</sup> = 0.113), visuospatial ability (<i>R</i><sup>2</sup> = 0.181), attention (<i>R</i><sup>2</sup> = 0.068), and orientation (<i>R</i><sup>2</sup> = 0.157). P300 latency correlated with: MoCA total (<i>R</i><sup>2</sup> = 0.141), visuospatial ability (<i>R</i><sup>2</sup> = 0.090), delayed recall (<i>R</i><sup>2</sup> = 0.112), and orientation (<i>R</i><sup>2</sup> = 0.082).</p>\\n </section>\\n \\n <section>\\n \\n <h3> CONCLUSION</h3>\\n \\n <p>Prolonged vestibular-related dizziness/vertigo in elderly patients is associated with cognitive deficits, particularly in visuospatial and executive functions. P300 latency demonstrates greater sensitivity than both P300 amplitude and MoCA screening, suggesting that combined electrophysiological and neuropsychological assessment enhances early detection of vestibular-related cognitive impairment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Long-duration vestibular-related dizziness or balance disorders are associated with a higher risk of cognitive impairment in elderly patients.</li>\\n \\n <li>Among early assessment tools, P300 latency proves more sensitive than both P300 amplitude and the Montreal Cognitive Assessment (MoCA) questionnaire.</li>\\n \\n <li>A combined evaluation using P300 latency and MoCA provides a more effective measure of how dizziness affects cognitive function in this population.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":53225,\"journal\":{\"name\":\"Alzheimer''s and Dementia: Translational Research and Clinical Interventions\",\"volume\":\"11 3\",\"pages\":\"\"},\"PeriodicalIF\":6.8000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70153\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer''s and Dementia: Translational Research and Clinical Interventions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70153\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","FirstCategoryId":"1085","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70153","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Vestibular-related dizziness duration and cognitive deficits in older adults
OBJECTIVE
The objective of this study is to investigate the relationship between symptom duration of vestibular-related dizziness/vertigo and cognitive function in elderly patients, and to establish clinical guidance for assessing and intervening in vestibular-related cognitive impairments.
METHODS
This study included 100 elderly patients with vestibular dysfunction presenting dizziness, vertigo, or balance disorders, categorized into short-duration (n = 64) and long-duration (n = 36) groups based on symptom duration. A control group of 21 healthy elderly individuals was included. Cognitive assessments comprised P300 event-related potentials (latency/amplitude) and Montreal Cognitive Assessment (MoCA) with domain-specific analysis.
RESULTS
Significant between-group differences in P300 latency were observed (control vs short-duration vs long-duration: p < 0.001), whereas amplitude showed no difference (p = 0.817). MoCA total scores differed significantly across groups (p = 0.001), although abnormality rates were comparable (p = 0.093). Domain analysis revealed significant differences in visuospatial (p < 0.001) and abstract abilities (p = 0.005). Symptom duration correlated with: MoCA total (R2 = 0.113), visuospatial ability (R2 = 0.181), attention (R2 = 0.068), and orientation (R2 = 0.157). P300 latency correlated with: MoCA total (R2 = 0.141), visuospatial ability (R2 = 0.090), delayed recall (R2 = 0.112), and orientation (R2 = 0.082).
CONCLUSION
Prolonged vestibular-related dizziness/vertigo in elderly patients is associated with cognitive deficits, particularly in visuospatial and executive functions. P300 latency demonstrates greater sensitivity than both P300 amplitude and MoCA screening, suggesting that combined electrophysiological and neuropsychological assessment enhances early detection of vestibular-related cognitive impairment.
Highlights
Long-duration vestibular-related dizziness or balance disorders are associated with a higher risk of cognitive impairment in elderly patients.
Among early assessment tools, P300 latency proves more sensitive than both P300 amplitude and the Montreal Cognitive Assessment (MoCA) questionnaire.
A combined evaluation using P300 latency and MoCA provides a more effective measure of how dizziness affects cognitive function in this population.
期刊介绍：
Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.
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