Tyler R Selkin, Varsha Manucha, Jing Xu, Doreen Palsgrove, Julia A Bridge, Justin A Bishop
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Novel BMPR1B::AFF2 in a Sinonasal Region Non-Keratinizing Squamous Cell Carcinoma.
Introduction: Molecular diagnostic tools may help resolve difficult differential diagnoses, and in some cases, they uncover entirely novel findings.
Methods: We performed immunohistochemistry and molecular analysis on a cytologically bland squamous tumor of the sinonasal region.
Results: We found a previously unreported BMPR1B::AFF2 fusion in a difficult-to-characterize nasal and nasopharyngeal tumor exhibiting aggressive local behavior and recurrence.
Conclusion: While the DEK::AFF2 fusion is well-characterized in sinonasal region tumors, alternate fusion partners are becoming increasingly recognized.
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