埃塞俄比亚烧伤患者治疗效果差及其决定因素系统回顾和荟萃分析

IF 1.8 4区医学 Q2 NURSING

International Emergency Nursing Pub Date : 2025-09-12 DOI:10.1016/j.ienj.2025.101676

Mengistu Abebe Messelu , Baye Tsegaye Amlak , Tadesse Yirga Akalu , Getnet Nibret Alemie , Salelign Amlaku Matebe , Mamaru Getie Fetene , Bekele Getenet Tiruneh , Ashenafi Fekad Getahun , Makda Fekadie Tewelgne , Tadesse Miretie Dessie , Yasab Leykun , Temesgen Ayenew

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引用次数: 0

摘要

背景烧伤仍然是一个主要的公共卫生问题，每年造成数千例可预防的死亡和残疾。因此，本综述和荟萃分析旨在评估全国不良治疗结果的发生率及其决定因素。方法本系统评价按照系统评价和荟萃分析首选报告项目（PRISMA）指南进行，并已在PROSPERO注册。对数据库（Medline/PubMed、谷歌Scholar、CINAHL、EMBASE、HINARI和Web of Science）进行了结构化搜索。研究的质量使用乔安娜布里格斯研究所（JBI）的关键评估工具进行评估。采用随机效应模型进行荟萃分析，以估计合并患病率和相关因素。采用I2统计来评估研究的异质性，并使用亚组分析和meta回归来确定异质性的可能原因。采用Egger检验和漏斗图评估发表偏倚。结果本系统综述和荟萃分析包括8项研究，共涉及9255例烧伤患者。埃塞俄比亚烧伤患者治疗结果不佳的全国总患病率为20.1% （95% CI: 14.14, 26.06）。区域亚组分析显示，提格雷、阿姆哈拉、奥罗米亚、南方民族和人民以及亚的斯亚贝巴的不良预后汇总估计分别为13.12%、29.24%、26.2%、25.6%和12.37%。此外，基于患者年龄的亚组分析显示，成人和儿童预后不良的汇总估计值分别为18.87%和21.58%。该荟萃分析表明，农村居民（OR = 3.24, 95% CI: 1.66, 6.33）、营养不良（OR = 3.17, 95% CI: 1.93, 5.19）、烧伤程度（OR = 2.60, 95% CI: 1.73, 3.90）和未得到充分的液体复苏（OR = 2.86, 95% CI: 1.36, 6.00）是烧伤患者临床预后不良的决定因素。结论与建议埃塞俄比亚五分之一的烧伤患者治疗效果不佳。作为农村居民，营养不良、烧伤程度（10%）和没有得到足够的液体复苏是治疗结果不良的重要预测因素。对农村地区、营养不良、脑面积较大的烧伤患者应给予特别关注。

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Poor treatment outcome and its determinants among patients with burn injuries in Ethiopia. A systematic review and meta-analysis

Background

Burn continues to be a major public health problem, resulting in thousands of preventable deaths and disabilities each year. Therefore, this review and meta-analysis aimed to assess the national prevalence of poor treatment outcome and its determinants.

Methods

This systematic review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and has been registered with PROSPERO. A structured search of databases (Medline/PubMed, Google Scholar, CINAHL, EMBASE, HINARI, and Web of Science) was undertaken. The quality of the studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool. A meta-analysis using a random-effects model was performed to estimate the pooled prevalence and associated factors. The I² statistics was used to assess the heterogeneity of studies, and to identify the possible causes of heterogeneity, subgroup analysis and meta-regression were used. Egger’s test and funnel plots were used to assess publication bias.

Results

This systematic review and meta-analysis included eight studies involving a total of 9255 burn patients. The pooled national prevalence of poor treatment outcome among burn patients in Ethiopia was 20.1 % (95 %CI: 14.14, 26.06). Regional subgroup analysis showed that the pooled estimate of poor outcome was 13.12 %, 29.24 %, 26.2 %, 25.6 %, and 12.37 % in Tigray, Amhara, Oromia, Southern Nation Nationalities and People, and Addis Ababa, respectively. Moreover, subgroup analysis based on patients’ age revealed that the pooled estimate of poor outcome among adults and children was 18.87 % and 21.58 %, respectively. This meta-analysis demonstrated that being a rural resident (OR = 3.24, 95 % CI: 1.66, 6.33), malnourished (OR = 3.17, 95 % CI: 1.93, 5.19), extent of burn > 10 % of TBSA (OR = 2.60, 95 % CI: 1.73, 3.90), and didn’t get adequate fluid resuscitation (OR = 2.86; 95 % CI: 1.36, 6.00) were determinants of poor clinical outcome for burn patients.

Conclusion and recommendations

One in every five burn patients in Ethiopia had poor treatment outcome. Being a rural resident, malnourished, extent of burn > 10 %, and no getting adequate fluid resuscitation were significant predictors of poor treatment outcome. Special attention should be given to burn injured patients from rural area, malnourished, and with larger TBSA.

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来源期刊

International Emergency Nursing NURSING-

CiteScore

3.20

自引率

11.10%

发文量

期刊介绍： International Emergency Nursing is a peer-reviewed journal devoted to nurses and other professionals involved in emergency care. It aims to promote excellence through dissemination of high quality research findings, specialist knowledge and discussion of professional issues that reflect the diversity of this field. With an international readership and authorship, it provides a platform for practitioners worldwide to communicate and enhance the evidence-base of emergency care. The journal publishes a broad range of papers, from personal reflection to primary research findings, created by first-time through to reputable authors from a number of disciplines. It brings together research from practice, education, theory, and operational management, relevant to all levels of staff working in emergency care settings worldwide.