卵巢癌化疗耐药中的自噬调节：分子机制和新兴前沿

IF 5.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-09-10 DOI:10.1016/j.lfs.2025.123966

Yi-Fan Yang, Lumeng Rui, Bo-Wen Zhang, Ting Huang, Gen-Bao Shao

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引用次数: 0

摘要

化疗耐药是目前卵巢癌患者死亡的主要原因。越来越多的数据表明，在这种恶性肿瘤中，自噬与化疗耐药密切相关。自噬是维持细胞稳态所必需的细胞内降解过程，当其失调时可促进化疗耐药。本文综述了自噬相关药物、蛋白、rna和通路干预如何影响卵巢癌化疗耐药及其潜在的分子机制的最新知识。它还概述了自噬和肿瘤之间更广泛的关系，特别关注卵巢癌。此外，我们根据自噬调节剂和常规化疗药物的协同作用，评估了联合治疗的潜力。尽管大多数研究表明自噬激活促进卵巢癌的顺铂耐药，但少数报道表明相反的作用。本文综述旨在为克服卵巢癌化疗耐药提供新的思路。耐药性是目前卵巢癌患者死亡的主要原因。越来越多的数据表明卵巢癌的自噬与化疗耐药密切相关。自噬是一种维持细胞稳态的细胞内降解过程。自噬失衡可导致卵巢癌化疗耐药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Autophagy regulation in ovarian cancer chemoresistance: Molecular mechanisms and emerging frontiers

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Autophagy regulation in ovarian cancer chemoresistance: Molecular mechanisms and emerging frontiers

Chemotherapy resistance is currently the primary cause of death in patients with ovarian cancer. An increasing amount of data indicates a close relationship between autophagy and chemotherapy resistance in this malignancy. Autophagy, an intracellular degradation process essential for maintaining cellular homeostasis, can promote chemotherapy resistance when dysregulated. This review synthesizes current knowledge on how autophagy-related drugs, proteins, RNAs, and pathway interventions influence chemoresistance in ovarian cancer, along with their underlying molecular mechanisms. It also outlines the broader relationship between autophagy and tumor, with a specific focus on ovarian cancer. Additionally, we evaluate the potential of combination therapies involving autophagy-modulating agents and conventional chemotherapeutic drugs, based on their synergistic effects. Although the majority of studies indicate that autophagy activation promotes cisplatin resistance in ovarian cancer, a minority of reports suggest opposing roles. This review aims to provide new perspectives for overcoming chemotherapy resistance in ovarian cancer. Resistance is currently the primary cause of death in patients with ovarian cancer. An increasing amount of data indicates a close relationship between autophagy and chemotherapy resistance in ovarian cancer. Autophagy is an intracellular degradation process that maintains cellular homeostasis. Imbalances in autophagy can lead to chemotherapy resistance in ovarian cancer.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.