视中隔发育不良儿童的睡眠障碍：一项回顾性队列研究

IF 2.1 3区医学 Q2 CLINICAL NEUROLOGY

Pediatric neurology Pub Date : 2025-08-21 DOI:10.1016/j.pediatrneurol.2025.08.013

Grae McCarty BA , Megana Iyer BS , Hana Danieli MD , Egambaram Senthilvel MD , Cemal Karakas MD , Emily Singer MD

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引用次数: 0

摘要

背景：视中隔发育不良（SOD）是一种异质性神经发育障碍，诊断基于以下两种或两种以上的表现：视神经发育不全，透明隔缺失和/或胼胝体发育不良，垂体激素异常。SOD引起的睡眠障碍很常见；然而，它们还没有被很好地描述。本研究探讨SOD患者的睡眠障碍。方法本研究为回顾性研究，纳入21岁以下诊断为SOD的儿童。收集睡眠史和多导睡眠图（PSG）数据。结果109例患者（男：女= 47:62）出现SOD。其中，61人（56%）有各种睡眠障碍，包括打鼾（n = 34; 56%）、失眠（n = 12; 20%）和/或频繁醒来（n = 8; 13%）。13例患者出现PSG，平均年龄5.2岁（sd: 3.02）。平均总睡眠时间为396.6分钟（标准差：81.21），平均睡眠潜伏期为35.01分钟（标准差：31.26），平均醒觉时间为72.9分钟（标准差：75.68）。平均睡眠效率为75.9%（标准差：26.6）；N1睡眠的平均百分比为0.38%（标准差：0.62），N2睡眠的平均百分比为41.8%（标准差：10.1），N3睡眠的平均百分比为38.7%（标准差：15.6），快速眼动睡眠的平均百分比为19.2%（标准差：11.3）。平均呼吸暂停低通气指数（AHI）为6.8 （sd 10.4）。REM期平均AHI为18.1（标准差：24.9）。平均觉醒指数为8.88（标准差：7.85）。结论SOD患者易出现睡眠障碍，存在睡眠片段化和阻塞性睡眠呼吸暂停的风险。这些患者可能受益于睡眠问题的定期筛查和睡眠医学专家的评估。

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Sleep Disturbances in Children With Septo-Optic Dysplasia: A Retrospective Cohort Study

Background

Septo-optic dysplasia (SOD) is a heterogeneous neurodevelopmental disorder diagnosed based on the presence of two or more of the following findings: optic nerve hypoplasia, absence of the septum pellucidum and/or dysgenesis of the corpus callosum, and pituitary hormone abnormalities. Sleep disturbances in SOD are common; however, they have not been well characterized. This study investigates sleep disturbances in patients with SOD.

Methods

This was a retrospective study that included children under age 21 years with a diagnosis of SOD. Sleep histories and polysomnographic (PSG) data were collected.

Results

109 patients (male:female = 47:62) with SOD were identified. Of these, 61 (56%) had various sleep disturbances, including snoring (n = 34; 56%), insomnia (n = 12; 20%), and/or frequent arousals (n = 8; 13%). Thirteen patients had PSG at a mean age of 5.2 years (S.D.: 3.02). Mean total sleep time was 396.6 minutes (S.D.: 81.21), mean sleep latency was 35.01 minutes (S.D.: 31.26), and mean wake after sleep onset was 72.9 (S.D.: 75.68). Mean sleep efficiency was 75.9% (S.D.: 26.6); mean percentage of N1 sleep was 0.38% (S.D.: 0.62), of N2 sleep was 41.8% (S.D.: 10.1), of N3 sleep was 38.7% (S.D.: 15.6), and of rapid eye movement (REM) was 19.2% (S.D.: 11.3). Mean apnea-hypopnea index (AHI) was 6.8 (S.D. 10.4). Mean REM AHI was 18.1 (S.D.: 24.9). Mean arousal index was 8.88 (S.D.: 7.85).

Conclusions

Patients with SOD frequently have sleep disturbance and are at risk for fragmented sleep and obstructive sleep apnea. These patients may benefit from regular screening of sleep problems and evaluation by sleep medicine specialists.

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.