{"title":"颅内颈动脉硬化与脑出血预后的关系。","authors":"Bo-Ching Lee, Hsin-Hsi Tsai, Ya-Fang Chen, Jiann-Shing Jeng, Li-Kai Tsai","doi":"10.1177/23969873241306576","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Intracerebral hemorrhage (ICH) is a manifestations of sporadic cerebral small vessel disease, and the survivors are predisposed to higher long-term risks of vascular events. Intracranial carotid artery calcification (ICAC), a potential marker for arteriosclerosis, is a risk factor for stroke but their roles in ICH is unknown. We aimed to investigate the prevalence and morphological subtypes of ICAC and their associations with long-term vascular events in ICH survivors.</p><p><strong>Materials and methods: </strong>Survivors of spontaneous ICH treated at a single center in Taiwan were included. ICAC was assessed by non-contrast CT; morphology was evaluated and categorized as intimal, internal elastic lamina (IEL), or mixed subtype. Patients were followed up for two years. Associations between calcification subtypes and follow-up events (stroke, cardiovascular event, death) were explored using multivariable Cox regression models.</p><p><strong>Results: </strong>Overall, 462 (80.1%) survivors of ICH had ICAC-223 (38.6%) were categorized as IEL calcification, 216 (37.4%) as intimal calcification, and 23 (4.0%) as mixed type calcification-and 115 patients (19.9%) had no calcification. Patients with IEL calcification were older than patients with intimal or no calcification (<i>p</i> < 0.001). Age (<i>p</i> < 0.001), diabetes (<i>p</i> = 0.010), and reduced renal function (<i>p</i> = 0.001) were independently associated with IEL calcification. During 2-years of follow-up, IEL calcification was not associated with a significant difference in the risk of recurrent ICH (HR=2.8 [0.8‒9.7]), but was associated with higher risks of incident ischemic stroke (HR = 9.0 [1.0‒77.4]), vascular mortality (HR = 13.6 [1.7‒1772.4], and all-cause mortality (HR = 13.9 [1.8‒105.8]).</p><p><strong>Conclusions: </strong>ICAC is common among ICH survivors and the subtype of IEL calcification may potentially have prognostic value for long-term vascular events.</p>","PeriodicalId":46821,"journal":{"name":"European Stroke Journal","volume":"10 3","pages":"738-747"},"PeriodicalIF":4.5000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683827/pdf/","citationCount":"0","resultStr":"{\"title\":\"Intracranial carotid arteriosclerosis and their prognosis in intracerebral hemorrhage.\",\"authors\":\"Bo-Ching Lee, Hsin-Hsi Tsai, Ya-Fang Chen, Jiann-Shing Jeng, Li-Kai Tsai\",\"doi\":\"10.1177/23969873241306576\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Intracerebral hemorrhage (ICH) is a manifestations of sporadic cerebral small vessel disease, and the survivors are predisposed to higher long-term risks of vascular events. Intracranial carotid artery calcification (ICAC), a potential marker for arteriosclerosis, is a risk factor for stroke but their roles in ICH is unknown. We aimed to investigate the prevalence and morphological subtypes of ICAC and their associations with long-term vascular events in ICH survivors.</p><p><strong>Materials and methods: </strong>Survivors of spontaneous ICH treated at a single center in Taiwan were included. ICAC was assessed by non-contrast CT; morphology was evaluated and categorized as intimal, internal elastic lamina (IEL), or mixed subtype. Patients were followed up for two years. Associations between calcification subtypes and follow-up events (stroke, cardiovascular event, death) were explored using multivariable Cox regression models.</p><p><strong>Results: </strong>Overall, 462 (80.1%) survivors of ICH had ICAC-223 (38.6%) were categorized as IEL calcification, 216 (37.4%) as intimal calcification, and 23 (4.0%) as mixed type calcification-and 115 patients (19.9%) had no calcification. Patients with IEL calcification were older than patients with intimal or no calcification (<i>p</i> < 0.001). Age (<i>p</i> < 0.001), diabetes (<i>p</i> = 0.010), and reduced renal function (<i>p</i> = 0.001) were independently associated with IEL calcification. During 2-years of follow-up, IEL calcification was not associated with a significant difference in the risk of recurrent ICH (HR=2.8 [0.8‒9.7]), but was associated with higher risks of incident ischemic stroke (HR = 9.0 [1.0‒77.4]), vascular mortality (HR = 13.6 [1.7‒1772.4], and all-cause mortality (HR = 13.9 [1.8‒105.8]).</p><p><strong>Conclusions: </strong>ICAC is common among ICH survivors and the subtype of IEL calcification may potentially have prognostic value for long-term vascular events.</p>\",\"PeriodicalId\":46821,\"journal\":{\"name\":\"European Stroke Journal\",\"volume\":\"10 3\",\"pages\":\"738-747\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683827/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Stroke Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/23969873241306576\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Stroke Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/23969873241306576","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:脑出血(ICH)是散发性脑血管疾病的一种表现,幸存者易发生血管事件的长期风险较高。颅内颈动脉钙化(ICAC)是动脉硬化的潜在标志,是卒中的危险因素,但其在脑出血中的作用尚不清楚。我们的目的是调查缺血性脑出血幸存者中廉政公署的患病率和形态学亚型及其与长期血管事件的关系。材料与方法:在台湾单一中心接受自发性脑出血治疗的幸存者。采用非对比CT评估廉政;形态学评估和分类为内膜、内弹性板(IEL)或混合亚型。患者随访2年。采用多变量Cox回归模型探讨钙化亚型与随访事件(脑卒中、心血管事件、死亡)之间的关系。结果:总体而言,462例(80.1%)脑出血幸存者有icac, 223例(38.6%)为IEL钙化,216例(37.4%)为内膜钙化,23例(4.0%)为混合型钙化,115例(19.9%)无钙化。IEL钙化患者比内膜钙化或无钙化患者年龄大(p p p = 0.010),肾功能下降(p = 0.001)与IEL钙化独立相关。在2年的随访中,IEL钙化与脑出血复发风险无显著性差异(HR=2.8[0.8-9.7]),但与缺血性卒中(HR= 9.0[1.0-77.4])、血管死亡率(HR= 13.6[1.7-1772.4]和全因死亡率(HR= 13.9[1.8-105.8])的发生率升高相关。结论:ICAC在脑出血幸存者中很常见,IEL钙化亚型可能对长期血管事件具有潜在的预后价值。
Intracranial carotid arteriosclerosis and their prognosis in intracerebral hemorrhage.
Background: Intracerebral hemorrhage (ICH) is a manifestations of sporadic cerebral small vessel disease, and the survivors are predisposed to higher long-term risks of vascular events. Intracranial carotid artery calcification (ICAC), a potential marker for arteriosclerosis, is a risk factor for stroke but their roles in ICH is unknown. We aimed to investigate the prevalence and morphological subtypes of ICAC and their associations with long-term vascular events in ICH survivors.
Materials and methods: Survivors of spontaneous ICH treated at a single center in Taiwan were included. ICAC was assessed by non-contrast CT; morphology was evaluated and categorized as intimal, internal elastic lamina (IEL), or mixed subtype. Patients were followed up for two years. Associations between calcification subtypes and follow-up events (stroke, cardiovascular event, death) were explored using multivariable Cox regression models.
Results: Overall, 462 (80.1%) survivors of ICH had ICAC-223 (38.6%) were categorized as IEL calcification, 216 (37.4%) as intimal calcification, and 23 (4.0%) as mixed type calcification-and 115 patients (19.9%) had no calcification. Patients with IEL calcification were older than patients with intimal or no calcification (p < 0.001). Age (p < 0.001), diabetes (p = 0.010), and reduced renal function (p = 0.001) were independently associated with IEL calcification. During 2-years of follow-up, IEL calcification was not associated with a significant difference in the risk of recurrent ICH (HR=2.8 [0.8‒9.7]), but was associated with higher risks of incident ischemic stroke (HR = 9.0 [1.0‒77.4]), vascular mortality (HR = 13.6 [1.7‒1772.4], and all-cause mortality (HR = 13.9 [1.8‒105.8]).
Conclusions: ICAC is common among ICH survivors and the subtype of IEL calcification may potentially have prognostic value for long-term vascular events.
期刊介绍:
Launched in 2016 the European Stroke Journal (ESJ) is the official journal of the European Stroke Organisation (ESO), a professional non-profit organization with over 1,400 individual members, and affiliations to numerous related national and international societies. ESJ covers clinical stroke research from all fields, including clinical trials, epidemiology, primary and secondary prevention, diagnosis, acute and post-acute management, guidelines, translation of experimental findings into clinical practice, rehabilitation, organisation of stroke care, and societal impact. It is open to authors from all relevant medical and health professions. Article types include review articles, original research, protocols, guidelines, editorials and letters to the Editor. Through ESJ, authors and researchers have gained a new platform for the rapid and professional publication of peer reviewed scientific material of the highest standards; publication in ESJ is highly competitive. The journal and its editorial team has developed excellent cooperation with sister organisations such as the World Stroke Organisation and the International Journal of Stroke, and the American Heart Organization/American Stroke Association and the journal Stroke. ESJ is fully peer-reviewed and is a member of the Committee on Publication Ethics (COPE). Issues are published 4 times a year (March, June, September and December) and articles are published OnlineFirst prior to issue publication.