评估降钙素原、c反应蛋白和白蛋白水平引导抗生素在败血症中的应用效果。

IF 1.5 4区医学 Q3 HEMATOLOGY

Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI:10.4084/MJHID.2025.060

Junyue Cao, Yuchao Sun

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引用次数: 0

摘要

背景：有效的脓毒症管理需要精确的抗生素治疗。本研究考察了使用降钙素原（PCT）、c反应蛋白（CRP）和白蛋白水平指导此类治疗的效果。方法：共有127名成年脓毒症患者被分配到标准护理组或生物标志物指导组，根据生物标志物水平调整抗生素使用。结果：生物标志物引导的方法显着缩短了抗生素治疗的持续时间（9.0天对10.5天，P=0.04）并加速了抗生素的降级。生物标志物引导组的住院费用较低（2万元对2.4万元，P=0.04），但继发感染的减少没有达到统计学意义。28天死亡率无显著差异。结论：生物标志物引导的抗生素治疗可提高脓毒症的治疗效率，在不影响患者安全的情况下减少持续时间和成本。这些发现表明将生物标志物纳入标准脓毒症管理方案的潜在益处。

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Assessment of the Efficacy of Procalcitonin, C-Reactive Protein, and Albumin Levels-guided Antibiotics Use in Sepsis.

Background: Efficient management of sepsis requires precise antibiotic therapy. This study examines the efficacy of guiding such therapy using Procalcitonin (PCT), C-Reactive Protein (CRP), and albumin levels.

Methods: A total of 127 adult sepsis patients were assigned to either standard care or a biomarker-guided group where antibiotic use was adjusted based on biomarker levels.

Results: The biomarker-guided approach significantly reduced the duration of antibiotic therapy (9.0 vs. 10.5 days, P=0.04) and expedited antibiotic de-escalation. Hospital costs were lower in the biomarker-guided group (20,000 vs. 24,000 CNY, P=0.04), though reductions in secondary infections did not reach statistical significance. There was no significant difference in 28-day mortality rates.

Conclusion: Biomarker-guided antibiotic therapy can enhance the efficiency of treatment in sepsis, reducing both duration and cost without impacting patient safety. These findings suggest the potential benefits of incorporating biomarkers into standard sepsis management protocols.

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来源期刊

Mediterranean Journal of Hematology and Infectious Diseases Medicine-Hematology

CiteScore

4.20

自引率

6.20%

发文量

113

审稿时长

12 weeks

期刊介绍： Reciprocal interdependence between infectious and hematologic diseases (malignant and non-malignant) is well known. This relationship is particularly evident in Mediterranean countries. Parasitosis as Malaria, Leishmaniosis, B Hookworms, Teniasis, very common in the southeast Mediterranean area, infect about a billion people and manifest prevalently with anemia so that they are usually diagnosed mostly by experienced hematologist on blood or bone marrow smear. On the other hand, infections are also a significant problem in patients affected by hematological malignancies. The blood is the primary vector of HIV infection, which otherwise manifest with symptoms related to a reduction in T lymphocytes. In turn, infections can favor the insurgency of hematological malignancies. The causative relationship between Epstein-Barr virus infection, Helicobacter pylori, hepatitis C virus, HIV and lymphoproliferative diseases is well known.