Odhisea Gazeli*, , , Constantinos Lazarou, , , Marcos Bouza, , , David Moreno-González, , , Charalambos Anastassiou, , , Joachim Franzke, , , Juan F. García-Reyes*, , and , George E. Georghiou,
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引用次数: 0
摘要
了解解吸机制对于优化分析技术至关重要,这些技术可以使冷凝相样品直接采样和电离而无需制备。低温等离子体(LTP)电离源,最早由Harper (Harper; et al.)描述。分析的。化学,2008,80,9097-9104),基于介质阻挡放电原理,是质谱(MS)中最具代表性和可复制的基于等离子体的环境解吸/电离工具之一,尽管有很多设计和配置。然而,与LTP和其他相关等离子体源直接相关的基本解吸机制仍不清楚。在这项研究中,我们使用COMSOL Multiphysics进行等离子体模拟,以了解放置在玻璃上的固体样品暴露于简化氦LTP配置的等离子体中的分析物释放情况。我们的模拟表明,由等离子体引起的样品-衬底表面电荷的积累导致了足够强的局部电场,可能有助于破坏分析物-衬底相互作用并促进脱附。重要的是,我们的模型估计等离子体中的电子能量约为2.5 eV,这表明这个模拟的能级是解吸效率的一个指标。我们的发现为等离子体诱导现象和解吸过程之间复杂的相互作用提供了新的见解。
Insight into Desorption Mechanisms in a Helium Low-Temperature Plasma Ionization Source Using Computational Simulations
Understanding desorption mechanisms is essential for the optimization of analytical techniques that enable the direct sampling and ionization of condensed-phase samples without preparation. The low-temperature plasma (LTP) ionization source, first described by Harper (Harper; et al. Anal. Chem.2008, 80, 9097–9104) and based on the dielectric barrier discharge principle, is among the more representative and replicated plasma-based ambient desorption/ionization tools for mass spectrometry (MS), although there are a wide array of designs and configurations. However, the fundamental desorption mechanisms directly associated with LTP and other related plasma-based sources remain unclear. In this study, we utilized plasma simulations using COMSOL Multiphysics to understand analyte release from solid samples placed on glass and exposed to the plasma of a simplified helium LTP configuration. Our simulations revealed that the accumulation of surface charge on the sample–substrate that is caused by the plasma results in localized electric fields strong enough to likely aid in disruption of analyte–substrate interactions and facilitate desorption. Importantly, our model estimates that electrons in plasma have energies of approximately 2.5 eV, suggesting this simulated energy level is an indicator for desorption efficiency. Our findings provide new insight into the complex interplay between plasma-induced phenomena and desorption processes.
期刊介绍:
The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role.
Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives