Brandon A. Yates, Ariela R. Orkaby, Jakob L. Vingren, Lawrence E. Armstrong
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Yet, how IC influences the magnitude of improvement following a single exercise bout has not been elucidated.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>A convenience sampling of 40 physically active adults (55 ± 6 years; mean ± SD) with a body mass index ≥ 24.9 kg/m<sup>2</sup> (range: 24.9 to 36.3) were included in this study. IC domains were operationally defined as follows: <i>cognitive</i> (Mini Cog and Trail Making Test Parts A and B [TMT A+B] performance), <i>vitality</i> (body composition and exercise performance), and <i>locomotor function</i> (habitual gait speed). Participants were stratified by <i>locomotor function</i> into a slow group (≤1.0 m/s; LOW-IC) and a normal group (>1.0 m/s; NORM-IC). Immediately prior to and following the exercise session (161-km cycling event) participants completed the executive function task (TMT A+B). An analysis of covariance, controlling for baseline TMT A+B performance, was used to detect a significant improvement in TMT A+B (<i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Participants had similar <i>cognitive abilities</i> and <i>vitality</i>, but groups significantly differed by <i>locomotor function</i>. A significant interaction (<i>p</i> = 0.004) was revealed where improvement for NORM-IC (−13 s [−18 to −8]; <i>p</i> < 0.001; partial <i>η<sup>2</sup></i> = 0.47; adjusted mean [95% confidence interval]) was greater than for LOW-IC (−3 s [−9 to 2]; <i>p</i> = 0.25; partial <i>η<sup>2</sup></i> = 0.04) following the exercise session.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Low IC is associated with a blunted acute exercise-induced cognitive enhancement in mid to late adulthood. Future research is justified to determine the physiological mechanisms underpinning this novel finding.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Adults with overweight/obesity show cognitive gains after endurance exercise.</li>\n \n <li>Poor locomotor function limits cognitive gains from exercise in overweight adults.</li>\n \n <li>IC better predicts exercise-related cognitive gains than cognition.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":53225,"journal":{"name":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","volume":"11 3","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70141","citationCount":"0","resultStr":"{\"title\":\"Low intrinsic capacity is associated with a blunted exercise-induced cognitive enhancement in physically active middle-aged and older adults\",\"authors\":\"Brandon A. 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An analysis of covariance, controlling for baseline TMT A+B performance, was used to detect a significant improvement in TMT A+B (<i>p</i> < 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Participants had similar <i>cognitive abilities</i> and <i>vitality</i>, but groups significantly differed by <i>locomotor function</i>. A significant interaction (<i>p</i> = 0.004) was revealed where improvement for NORM-IC (−13 s [−18 to −8]; <i>p</i> < 0.001; partial <i>η<sup>2</sup></i> = 0.47; adjusted mean [95% confidence interval]) was greater than for LOW-IC (−3 s [−9 to 2]; <i>p</i> = 0.25; partial <i>η<sup>2</sup></i> = 0.04) following the exercise session.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>Low IC is associated with a blunted acute exercise-induced cognitive enhancement in mid to late adulthood. 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Low intrinsic capacity is associated with a blunted exercise-induced cognitive enhancement in physically active middle-aged and older adults
INTRODUCTION
The World Health Organization supports intrinsic capacity (IC) as a framework for assessing and monitoring an older person's cognitive health. Low IC is associated with higher dementia risk. Regular exercise participation improves cognitive health, reduces dementia risk, and may increase IC. However, the long-term chronic brain benefits of regular exercise training are dependent upon the effectiveness of single exercise bouts to augment cognition. Yet, how IC influences the magnitude of improvement following a single exercise bout has not been elucidated.
METHODS
A convenience sampling of 40 physically active adults (55 ± 6 years; mean ± SD) with a body mass index ≥ 24.9 kg/m2 (range: 24.9 to 36.3) were included in this study. IC domains were operationally defined as follows: cognitive (Mini Cog and Trail Making Test Parts A and B [TMT A+B] performance), vitality (body composition and exercise performance), and locomotor function (habitual gait speed). Participants were stratified by locomotor function into a slow group (≤1.0 m/s; LOW-IC) and a normal group (>1.0 m/s; NORM-IC). Immediately prior to and following the exercise session (161-km cycling event) participants completed the executive function task (TMT A+B). An analysis of covariance, controlling for baseline TMT A+B performance, was used to detect a significant improvement in TMT A+B (p < 0.05).
RESULTS
Participants had similar cognitive abilities and vitality, but groups significantly differed by locomotor function. A significant interaction (p = 0.004) was revealed where improvement for NORM-IC (−13 s [−18 to −8]; p < 0.001; partial η2 = 0.47; adjusted mean [95% confidence interval]) was greater than for LOW-IC (−3 s [−9 to 2]; p = 0.25; partial η2 = 0.04) following the exercise session.
DISCUSSION
Low IC is associated with a blunted acute exercise-induced cognitive enhancement in mid to late adulthood. Future research is justified to determine the physiological mechanisms underpinning this novel finding.
Highlights
Adults with overweight/obesity show cognitive gains after endurance exercise.
Poor locomotor function limits cognitive gains from exercise in overweight adults.
IC better predicts exercise-related cognitive gains than cognition.
期刊介绍：
Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.
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