模仿卵巢癌的皮肤黑色素瘤引起的晚期腹膜癌。

IF 1.9 4区 医学 Q3 DERMATOLOGY
Stefano Fucina, Lucia Lerda, Anna Del Fabro, Claudio Reato, Emilio Lucia, Nicolò Clemente, Fabio Puglisi, Michele Bartoletti, Antonio Palumbo, Vincenzo Canzonieri, Antonino Ditto
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引用次数: 0

摘要

腹膜癌是一种非常罕见的皮肤恶性黑色素瘤的转移模式,发生在不到1%的远处扩散病例中,通常发生在初次治疗后的头几年。本报告提出一个不寻常的病例,无病间期明显延长,临床模拟晚期卵巢癌。我们报告一例53岁的妇女治疗超过10年前的IIB期结节性黑色素瘤手术和辅助治疗。患者表现为进行性腹胀。影像显示双侧附件肿块、腹水、腹膜癌及多发肺结节,初步提示晚期卵巢癌。诊断性腹腔镜显示弥漫性腹膜病变,非典型的淡黄色、柔软和无色素外观。组织学和免疫组织化学证实转移性黑色素瘤。本病例是为数不多的黑素瘤腹膜癌病的报道之一,经过十多年的缓解。长时间的无病间隔和非典型表现强调了黑色素瘤的异质性行为和长期警惕和多学科评估的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Late peritoneal carcinomatosis from cutaneous melanoma mimicking ovarian cancer.

Peritoneal carcinomatosis represents an exceptionally rare metastatic pattern of cutaneous malignant melanoma, occurring in fewer than 1% of cases with distant spread and typically within the first few years after primary treatment. This report presents an unusual case with a markedly prolonged disease-free interval, clinically mimicking advanced ovarian carcinoma. We report the case of a 53-year-old woman treated more than 10 years ago for stage IIB nodular melanoma with surgery and adjuvant therapy. The patient presented with progressive abdominal bloating. Imaging revealed bilateral adnexal masses, ascites, peritoneal carcinomatosis, and multiple pulmonary nodules, initially suggestive of advanced ovarian cancer. Diagnostic laparoscopy demonstrated diffuse peritoneal lesions with an atypical yellowish, soft, and nonpigmented appearance. Histology and immunohistochemistry confirmed metastatic melanoma. This case is among the few reports of peritoneal carcinomatosis from melanoma after more than a decade of remission. The prolonged disease-free interval and atypical presentation underline the heterogeneous behavior of melanoma and the need for long-term vigilance and multidisciplinary evaluation.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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