植物基疫苗的最新进展：从分子农业创新到全球健康应用。

IF 3.1 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Biotechnology Journal Pub Date : 2025-09-10 DOI:10.1002/biot.70120

Yuting Shi, Qingsong Jiao, Xueyun Hu, Ting Jia

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引用次数: 0

摘要

疫苗通过降低感染率、严重程度和死亡率，在减轻传染病方面发挥着关键作用。植物源性疫苗经过改造，在植物中表达抗原，具有独特的优势，包括生产成本效益高、生物安全性强、热稳定性好和物流简化。植物生物技术的最新进展使植物基疫苗能够大规模生产，使其成为传统疫苗平台的可行和变革性替代品。这篇综述综合了最新进展，确定了主要挑战，并探讨了植物基疫苗开发的未来方向。通过强调植物生物技术在疫苗生产中的变革潜力，这项工作强调了植物生物学在促进全球健康方面的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent Advances in Plant-Based Vaccines: From Molecular Farming Innovations to Global Health Applications

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Recent Advances in Plant-Based Vaccines: From Molecular Farming Innovations to Global Health Applications

Vaccines are pivotal in mitigating infectious diseases by reducing infection rates, severity, and mortality. Plant-derived vaccines—engineered to express antigens in plants, offer distinctive advantages, including cost-efficient production, enhanced biosafety profiles, superior thermal stability, and simplified logistics. Recent advances in plant biotechnology have enabled the large-scale production of plant-based vaccines, positioning them as a viable and transformative alternative to conventional vaccine platforms. This review synthesizes the latest advances, identifies key challenges, and explores future directions in plant-based vaccine development. By highlighting the transformative potential of plant biotechnology in vaccine manufacturing, this work underscores the critical role of plant biology in advancing global health.

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来源期刊

Biotechnology Journal Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

8.90

自引率

2.10%

发文量

123

审稿时长

1.5 months

期刊介绍： Biotechnology Journal (2019 Journal Citation Reports: 3.543) is fully comprehensive in its scope and publishes strictly peer-reviewed papers covering novel aspects and methods in all areas of biotechnology. Some issues are devoted to a special topic, providing the latest information on the most crucial areas of research and technological advances. In addition to these special issues, the journal welcomes unsolicited submissions for primary research articles, such as Research Articles, Rapid Communications and Biotech Methods. BTJ also welcomes proposals of Review Articles - please send in a brief outline of the article and the senior author''s CV to the editorial office. BTJ promotes a special emphasis on: Systems Biotechnology Synthetic Biology and Metabolic Engineering Nanobiotechnology and Biomaterials Tissue engineering, Regenerative Medicine and Stem cells Gene Editing, Gene therapy and Immunotherapy Omics technologies Industrial Biotechnology, Biopharmaceuticals and Biocatalysis Bioprocess engineering and Downstream processing Plant Biotechnology Biosafety, Biotech Ethics, Science Communication Methods and Advances.