基于细离子迁移率的低分子量炸药分析。

IF 2.7 2区 化学 Q2 BIOCHEMICAL RESEARCH METHODS
Heidi M. Sabatini,  and , Christopher D. Chouinard*, 
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引用次数: 0

摘要

由于样品的潜在复杂性和异构体化合物的存在,爆炸性化合物的检测和鉴别仍然是安全应用和法医工作的关键组成部分。独立离子迁移谱法(IMS)已经在安全筛选中使用了几十年,它能够根据大小、形状和电荷的差异快速分离气相离子。最近开发的高分辨率离子迁移-质谱(HRIM-MS)方法结合了更高的分辨率和精确的质量测量,以提供改进的异构体分离和未知物的鉴定。这项工作采用了一种新颖的结构无损离子操作(SLIM)离子迁移平台,该平台具有圆形转弯设计,可以利用氦气缓冲气体增强低质量爆炸性化合物的传输。利用负模大气压化学电离(APCI),我们证明了2,4-对2,6-二硝基甲苯(2,4-/2,6- dnt)和2-氨基-4,6-对4-氨基-2,6- dnt等异构体硝基芳香族化合物的分离。与传统的90°转弯系统相比,圆转弯SLIM设计显著提高了离子传输效率,特别是对于这些低m/z分析物。由此,我们证明了SLIM HRIM-MS结合迁移率分离,精确质量和同位素模式的能力,以改进同分异构体炸药的分离和鉴定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

SLIM Ion Mobility-Based Analysis of Low Molecular Weight Explosives

SLIM Ion Mobility-Based Analysis of Low Molecular Weight Explosives

The detection and differentiation of explosive compounds remain critical components of security applications and forensic work due to the potential complexity of samples and presence of isomeric compounds. Standalone ion mobility spectrometry (IMS) has been used in security screening for decades, useful for its ability to rapidly separate gas-phase ions based on differences in their size, shape, and charge. More recently developed high-resolution ion mobility-mass spectrometry (HRIM-MS) methods incorporate higher resolving power with accurate mass measurements to provide improved isomer separations and identification of unknowns. This work utilizes a novel Structures for Lossless Ion Manipulations (SLIM) ion mobility platform featuring a rounded turn design, which enhances the transmission of low-mass explosive compounds using helium buffer gas. Using negative mode atmospheric pressure chemical ionization (APCI), we demonstrate separation of isomeric nitroaromatic compounds such as 2,4- vs 2,6-dinitrotoluene (2,4-/2,6-DNT) and 2-amino-4,6- vs 4-amino-2,6-DNT. The rounded turn SLIM design significantly improved ion transmission efficiency over the traditional 90° turn system, especially for these low m/z analytes. With this, we demonstrate the ability of SLIM HRIM-MS to combine mobility separations, accurate mass, and isotopic patterns for improved separation and identification of isomeric explosives.

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来源期刊
CiteScore
5.50
自引率
9.40%
发文量
257
审稿时长
1 months
期刊介绍: The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role. Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives
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