颅-脑膜-脑连通性和轴外脑肿瘤。

IF 4.5 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI:10.1093/braincomms/fcaf311
Abdurrahman I Islim, Alexandros Vyziotis, Omar N Pathmanaban, David J Coope, Andrew T King, David Brough, Laura Jardine, Kevin N Couper, Andrew D Greenhalgh
{"title":"颅-脑膜-脑连通性和轴外脑肿瘤。","authors":"Abdurrahman I Islim, Alexandros Vyziotis, Omar N Pathmanaban, David J Coope, Andrew T King, David Brough, Laura Jardine, Kevin N Couper, Andrew D Greenhalgh","doi":"10.1093/braincomms/fcaf311","DOIUrl":null,"url":null,"abstract":"<p><p>The cortex of the brain is covered by three meningeal layers: the dura, the arachnoid, and the pia mater. Substantial discoveries have been made demonstrating the structural and functional relationships between these layers, and with other neighbouring structures such as the skull. Importantly, improved understanding of the meningeal lymphatic network places the meninges at the nexus of a cross talk between the brain, peripheral immune system, and the skull bone marrow. The meningeal lymphatic network has been shown to regulate immune responses in models of health and disease states, such as intra-axial brain tumours, affecting a tumour's behaviour. Unsurprisingly, a diverse array of resident and circulating immune cells such as macrophages, T-cells and B-cells can be found in the meninges, with specialized organizations or hubs surrounding the dural venous sinuses and cranial nerves. Meningioma and vestibular schwannoma are the most common extra-axial brain tumours, with varying clinical courses related to their immune microenvironments. These tumours commonly occur in proximity to the immune hubs of the meninges. This could point towards a possible bidirectional interaction, not only implicated in regulating tumour immune cell infiltration, but also meningeal inflammation and symptoms such as headaches and anxiety. This review will summarize the meningeal structure and function and highlight how these may be linked to patients with meningioma or vestibular schwannoma.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 5","pages":"fcaf311"},"PeriodicalIF":4.5000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416566/pdf/","citationCount":"0","resultStr":"{\"title\":\"Skull-meninges-brain connectivity and extra-axial brain tumours.\",\"authors\":\"Abdurrahman I Islim, Alexandros Vyziotis, Omar N Pathmanaban, David J Coope, Andrew T King, David Brough, Laura Jardine, Kevin N Couper, Andrew D Greenhalgh\",\"doi\":\"10.1093/braincomms/fcaf311\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The cortex of the brain is covered by three meningeal layers: the dura, the arachnoid, and the pia mater. Substantial discoveries have been made demonstrating the structural and functional relationships between these layers, and with other neighbouring structures such as the skull. Importantly, improved understanding of the meningeal lymphatic network places the meninges at the nexus of a cross talk between the brain, peripheral immune system, and the skull bone marrow. The meningeal lymphatic network has been shown to regulate immune responses in models of health and disease states, such as intra-axial brain tumours, affecting a tumour's behaviour. Unsurprisingly, a diverse array of resident and circulating immune cells such as macrophages, T-cells and B-cells can be found in the meninges, with specialized organizations or hubs surrounding the dural venous sinuses and cranial nerves. Meningioma and vestibular schwannoma are the most common extra-axial brain tumours, with varying clinical courses related to their immune microenvironments. These tumours commonly occur in proximity to the immune hubs of the meninges. This could point towards a possible bidirectional interaction, not only implicated in regulating tumour immune cell infiltration, but also meningeal inflammation and symptoms such as headaches and anxiety. This review will summarize the meningeal structure and function and highlight how these may be linked to patients with meningioma or vestibular schwannoma.</p>\",\"PeriodicalId\":93915,\"journal\":{\"name\":\"Brain communications\",\"volume\":\"7 5\",\"pages\":\"fcaf311\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416566/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/braincomms/fcaf311\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/braincomms/fcaf311","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

大脑皮层由三层脑膜覆盖:硬脑膜、蛛网膜和硬脑膜。大量的发现证明了这些层之间的结构和功能关系,以及与其他邻近结构(如头骨)的关系。重要的是,对脑膜淋巴网络的进一步了解将脑膜置于大脑、外周免疫系统和颅骨骨髓之间的串扰的连接点。脑膜淋巴网络已被证明可以调节健康和疾病状态模型中的免疫反应,例如影响肿瘤行为的轴内脑瘤。不出所料,在脑膜中可以发现各种各样的常驻和循环免疫细胞,如巨噬细胞、t细胞和b细胞,在硬脑膜静脉窦和脑神经周围有专门的组织或中心。脑膜瘤和前庭神经鞘瘤是最常见的轴外脑肿瘤,其临床病程与其免疫微环境有关。这些肿瘤通常发生在脑膜免疫中枢附近。这可能指向一种可能的双向相互作用,不仅涉及调节肿瘤免疫细胞浸润,还涉及脑膜炎症和头痛、焦虑等症状。这篇综述将总结脑膜的结构和功能,并强调这些可能与脑膜瘤或前庭神经鞘瘤的患者有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Skull-meninges-brain connectivity and extra-axial brain tumours.

Skull-meninges-brain connectivity and extra-axial brain tumours.

Skull-meninges-brain connectivity and extra-axial brain tumours.

Skull-meninges-brain connectivity and extra-axial brain tumours.

The cortex of the brain is covered by three meningeal layers: the dura, the arachnoid, and the pia mater. Substantial discoveries have been made demonstrating the structural and functional relationships between these layers, and with other neighbouring structures such as the skull. Importantly, improved understanding of the meningeal lymphatic network places the meninges at the nexus of a cross talk between the brain, peripheral immune system, and the skull bone marrow. The meningeal lymphatic network has been shown to regulate immune responses in models of health and disease states, such as intra-axial brain tumours, affecting a tumour's behaviour. Unsurprisingly, a diverse array of resident and circulating immune cells such as macrophages, T-cells and B-cells can be found in the meninges, with specialized organizations or hubs surrounding the dural venous sinuses and cranial nerves. Meningioma and vestibular schwannoma are the most common extra-axial brain tumours, with varying clinical courses related to their immune microenvironments. These tumours commonly occur in proximity to the immune hubs of the meninges. This could point towards a possible bidirectional interaction, not only implicated in regulating tumour immune cell infiltration, but also meningeal inflammation and symptoms such as headaches and anxiety. This review will summarize the meningeal structure and function and highlight how these may be linked to patients with meningioma or vestibular schwannoma.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.00
自引率
0.00%
发文量
0
审稿时长
6 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信