并发抗雄激素治疗在复发性前列腺癌的补救性放疗设置：文献综述

IF 2.6 2区医学 Q2 UROLOGY & NEPHROLOGY

Prostate International Pub Date : 2025-09-01 DOI:10.1016/j.prnil.2024.11.001

Dhiraj Mannar, Ryan Urban, Tina Zhang, Michael Peacock

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引用次数: 0

摘要

根治性前列腺切除术广泛用于治疗局限性前列腺癌；然而，尽管进行了手术治疗，20%-50%的患者仍会出现疾病进展。这些患者的治疗包括补救性放疗（SRT），在大约50%具有侵袭性预后因素的病例中，其疗效从治愈到疾病进展不等。基于抗雄激素治疗（AAT）与前列腺癌明确放疗联合治疗的成功，有人认为AAT的加入可能使接受SRT的患者受益。在这里，我们回顾了围绕在这种情况下AAT的基本原理的文献，并综合了几个关键试验的结果，评估了在SRT环境下AAT的益处。

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Concurrent antiandrogen therapy in the salvage radiotherapy setting for recurrent prostate cancer: a literature review

Radical prostatectomy is widely used to treat localized prostate cancer; however, 20%-50% of patients will experience disease progression despite surgical management. Management of these patients involves salvage radiotherapy (SRT), which has variable efficacy ranging from cure to disease progression in roughly 50% of cases with aggressive prognostic factors. Based on the success in combining antiandrogen therapy (AAT) with definitive radiotherapy for prostate cancer, it has been suggested that the addition of AAT may benefit patients receiving SRT. Here we review the literature surrounding the rationale for AAT in this setting and synthesize the results of several key trials assessing the benefits of AAT within the SRT setting.

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来源期刊

Prostate International Medicine-Urology

CiteScore

4.40

自引率

26.70%

发文量

审稿时长

35 days

期刊介绍： Prostate International (Prostate Int, PI), the official English-language journal of Asian Pacific Prostate Society (APPS), is an international peer-reviewed academic journal dedicated to basic and clinical studies on prostate cancer, benign prostatic hyperplasia, prostatitis, and ...