泌尿生殖系统相关肿瘤和冠状动脉粥样硬化风险：来自多队列孟德尔随机化研究的证据

IF 5 2区医学 Q2 Medicine

Translational Oncology Pub Date : 2025-09-10 DOI:10.1016/j.tranon.2025.102527

Shanshan Chen , Yuanyuan Zhao , Yang Fan , Mengchen Zhou

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引用次数: 0

摘要

心血管疾病和癌症是全球死亡的主要原因。越来越多的证据表明，癌症患者患心血管疾病的风险显著增加。新出现的证据表明，这些疾病之间存在双向联系，可能是由激素变化介导的，但需要进一步的研究来探索激素水平变化在这两种疾病中的具体作用。方法采用GWAS汇总统计数据对前列腺癌、ER+乳腺癌和冠状动脉粥样硬化患者进行双样本孟德尔随机化（MR）分析。结果smr分析（IVW, MR-Egger， WM）显示前列腺癌和ER+乳腺癌与冠状动脉粥样硬化风险增加之间存在显著的因果关系。结论激素相关性泌尿生殖系统肿瘤可能参与冠状动脉粥样硬化的发生发展。这项研究是第一次使用磁共振成像为这种关联提供因果证据。

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Genitourinary system related tumors and coronary atherosclerosis risk: Evidence from a Mendelian randomization study on multi-cohorts

Background

CVD and cancer are the leading causes of mortality globally. Accumulating evidence suggests that cancer patients have a significantly increased risk of cardiovascular disease. Emerging evidence suggests a bidirectional link between these diseases, possibly mediated by hormonal changes, but further research needs to be performed to explore the specific role of hormone level changes in both diseases.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis using GWAS summary statistics from multiple cohorts of prostate cancer, ER+ breast cancer, and coronary atherosclerosis.

Results

MR analyses (IVW, MR-Egger, WM) demonstrated a significant causal relationship between both prostate and ER+ breast cancer and increased risk of coronary atherosclerosis.

Conclusion

Hormone-related genitourinary tumors may contribute to the development of coronary atherosclerosis. This study is the first to provide causal evidence for such associations using MR.

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来源期刊

Translational Oncology ONCOLOGY-

CiteScore

8.40

自引率

2.00%

发文量

314

审稿时长

54 days

期刊介绍： Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.